Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics.
Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics.
复制标题
非哮喘患者 6 岁时的链格孢过敏与随后的气道高反应性相关。
DOI：
10.1136/thoraxjnl-2017-210325
复制
发表时间：
2018
期刊：
影响因子：
10
通讯作者：
Morgan,WayneJ
中科院分区：
文献类型：
--
作者：
Hiranrattana,Anunya;Stern,DebraA;Guerra,Stefano;Halonen,Marilyn;Wright,AnneL;Daines,Michael;Martinez,FernandoD;Morgan,WayneJ
在非选择性出生队列图森儿童呼吸研究中，在非哮喘患者中，对链格孢菌的早期敏感性与成年后气道高反应性（AHR）增加有关。AHR的增加幅度与链格孢菌致敏哮喘患者相似，主要在超重或肥胖患者中明显。与此相反，在非哮喘患者中，除链格孢菌外，对空气过敏原的早期致敏与AHR之间没有显著相关性。为什么这组链格孢菌致敏的无哮喘个体表现出与哮喘患者相似的AHR增加尚不清楚，需要进一步研究。
In the non-selected birth cohort Tucson Children’s Respiratory Study, early sensitisation toAlternariawas associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen forAlternariasensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other thanAlternariaand AHR among non-asthmatics. Why this group ofAlternariasensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.