The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia
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DOI：
10.1213/01.ane.0000229716.39977.fa
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发表时间：
2006-09-01
影响因子：
5.7
通讯作者：
Wallace, Mark S.
中科院分区：
文献类型：
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作者：
Kumar, Keeran;Polston, Greg R.;Wallace, Mark S.
临床前和临床研究强调，持续的小传入输入会诱发中枢促进状态，而全身施用非甾体抗炎药可以减弱这种状态。然而，这些研究是使用痛觉过敏的皮肤模型进行的。在这项研究中，我们评估了静脉注射酮咯酸对使用肌肉注射辣椒素的深部组织痛觉过敏实验模型的影响。我们采用了双盲、安慰剂对照、交叉设计。 10 名受试者分 2 次接受 60 毫克酮咯酸或安慰剂治疗，间隔 1 周。然后将辣椒素（10μL中的100μg）注射到左前臂的尺侧腕屈肌中。注射后0、5、10、15、20和25分钟记录自发痛评分、压痛评分、抓握痛、疼痛分布和疼痛质量。然后绘制皮肤异常性疼痛和感觉迟钝的图，并测量热阈值和机械阈值。肌内注射辣椒素产生了关于疼痛、痛觉过敏和牵涉痛的可靠报告。酮咯酸对自发性疼痛、诱发疼痛、疼痛分布或辣椒素引起的继发性痛觉过敏没有影响。本研究的结果支持使用 IM 辣椒素疼痛模型进行进一步药理学研究的可行性。
Preclinical and clinical studies have emphasized that persistent small afferent input will induce a state of central facilitation that can be attenuated by systemically administered nonsteroidal antiinflammatory drugs. However, these studies have been performed using cutaneous models of hyperalgesia. In this study we evaluated them effects of IV ketorolac on an experimental model of deep tissue hyperalgesia using IM capsaicin. We used a double-blind, placebo-controlled, crossover design. Ten subjects received 60 mg of ketorolac or placebo in 2 sessions separated by 1 wk. Capsaicin (100 mu g in 10 mu L) was then injected into the flexor carpi ulnaris muscle of the left forearm. After injection, spontaneous pain scores, pressure pain scores, gripping pain, pain distribution, and pain quality were recorded at 0, 5, 10, 15, 20, and 25 min. Cutaneous allodynia and dysesthesia were then mapped and thermal and mechanical thresholds were measured. The IM injection of capsaicin resulted in a reliable report of pain, hyperalgesia, and referred pain. Ketorolac had no effect on spontaneous pain, elicited pain, pain distribution, or secondary hyperalgesia induced by capsaicin. The findings of this study support the feasibility of further pharmacological studies using the IM capsaicin pain model.