Low bone mineral density and risk of fracture in white female nursing home residents
Low bone mineral density and risk of fracture in white female nursing home residents
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DOI：
10.1001/jama.284.8.972
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发表时间：
2000-08-23
影响因子：
120.7
通讯作者：
Magaziner, J
中科院分区：
文献类型：
--
作者：
Chandler, JM;Zimmerman, SI;Magaziner, J
背景低骨矿物质密度（BMD）是社区居住的白色女性骨折的一个强有力的危险因素，但在白色女性养老院居民中，骨折率最高的关系不太清楚。目的评估低BMD对养老院居民骨折风险的相对贡献。设计前瞻性队列研究，基线数据收集于1995年4月至1997年6月。进行18个月的随访。设置在马里兰州随机选择的47家疗养院。患者总计1427名65岁或以上的白色女性疗养院居民。主要结果测量记录了随访期间发生的骨质疏松性骨折，作为基线骨密度测量值高于与低于中位数的函数，并在控制人口统计学、功能、认知、心理社会、结果180例妇女共发生桡骨骨折223例。低骨密度和转移独立性是该疗养院样本中骨折的重要独立危险因素（P
Context Low bone mineral density (BMD) is a strong risk factor for fracture in community-dwelling white women, but the relationship in white female nursing home residents, for whom fracture rates are highest, is less clear,Objective To assess the relative contribution of low BMD to fracture risk in nursing home residents.Design Prospective cohort study with baseline data collected April 1995 to June 1997, with 18 months of follow-up.Setting Forty-seven randomly selected nursing homes in Maryland.Patients A total of 1427 white female nursing home residents aged 65 years or older.Main Outcome Measure Documented osteoporotic fracture occurring during follow-up as a function of baseline BMD measurements higher vs lower than the median, and after controlling for demographic, functional, cognitive, psychosocial, and medical factors.Results A total of 223 osteoporotic fractures occurred among 180 women. Low BMD and transfer independence were significant independent risk factors for fracture in this nursing home sample (P