In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI
In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI
复制标题
DOI：
10.1038/jcbfm.2012.196
复制
发表时间：
2013-03-01
影响因子：
6.3
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
--
作者：
van Veluw, Susanne J.;Zwanenburg, Jaco J. M.;Biessels, Geert Jan
脑血管病在认知能力下降和痴呆中起着重要作用。在这种情况下，脑微梗死引起了越来越多的关注，但这些病变到目前为止还不能在体内检测到。本研究的目的是试图通过高分辨率7T活体磁共振成像（MRI）识别可能的皮层微梗死，并对死后脑组织的7T离体MRI上出现的类似病变进行组织病理学验证研究。研究人群包括22名老年受试者，他们接受了7T MRI检查。检查这些受试者的液体衰减反转恢复、T-2和T-1加权扫描是否存在可能的皮质微梗死。在离体MRI研究中，对6例阿尔茨海默病伴血管病变患者的15片福尔马林固定冠状脑切片进行了检查和组织病理学验证。在体内扫描中，在6名受试者中可以识别出可能是微梗死的15个皮质病变。在死后组织中，发现了6个类似的病灶，其中5个在组织病理学上被证实为皮质微梗死。本研究为在体内检测皮层微梗死提供了强有力的证据，这对进一步研究血管疾病在认知能力下降和痴呆中的作用具有重要价值。脑血流与代谢杂志（2013）33,322-329；doi: 10.1038 / jcbfm.2012.196;2012年12月19日在线发布
Cerebrovascular disease has an important role in cognitive decline and dementia. In this context, cerebral microinfarcts are attracting increasing attention, but these lesions could thus far not be detected in vivo. The aim of this study was to try to identify possible cortical microinfarcts on high-resolution 7T in vivo magnetic resonance imaging (MRI) and to perform a histopathologic validation study on similar appearing lesions on 7T ex vivo MRI of postmortem brain tissue. The study population consisted of 22 elderly subjects, who underwent 7T MRI. The fluid attenuated inversion recovery, T-2, and T-1 weighted scans of these subjects were examined for possible cortical microinfarcts. In the ex vivo MRI study, 15 formalin-fixed coronal brain slices of 6 subjects with Alzheimer and vascular pathology were examined and subjected to histopathologic verification. On the in vivo scans, 15 cortical lesions could be identified that were likely to be microinfarcts in 6 subjects. In the postmortem tissue, 6 similar appearing lesions were identified of which 5 were verified as cortical microinfarcts on histopathology. This study provides strong evidence that cortical microinfarcts can be detected in vivo, which will be of great value in further studies into the role of vascular disease in cognitive decline and dementia. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 322-329; doi:10.1038/jcbfm.2012.196; published online 19 December 2012