Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis.
Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis.
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DOI：
10.3390/toxins8070209
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发表时间：
2016-07-07
期刊：
影响因子：
4.2
通讯作者：
Lavigne JP
中科院分区：
文献类型：
--
作者：
Dunyach-Remy C;Ngba Essebe C;Sotto A;Lavigne JP
足部溃疡感染是糖尿病中常见的，通常严重且昂贵的并发症。糖尿病足感染（DFI）主要是多种微生物，金黄色葡萄球菌是最常见的病原体分离。S.金黄色葡萄球菌在感染期间的特征很好。然而，在《伊拉克发展倡议》中可以观察到一些特殊的特点。本文综述了S.金黄色葡萄球菌在DFI和其毒素在建立感染的影响。对这一问题的研究有助于区分两个S。DFI中的金黄色葡萄球菌群体：产毒S.金黄色葡萄球菌菌株（携带剥脱蛋白-、EDIN-、PVL-或TSST-编码基因）和非产毒素菌株。产毒素菌株通常存在于具有更严重等级和全身影响的感染中，而非产毒素菌株似乎仍然局限于涉及糖尿病足骨髓炎的深部结构和骨骼中。测试细菌的毒力谱似乎是预测S.金黄色葡萄球菌在慢性伤口。
Infection of foot ulcers is a common, often severe and costly complication in diabetes. Diabetic foot infections (DFI) are mainly polymicrobial, and Staphylococcus aureus is the most frequent pathogen isolated. The numerous virulence factors and toxins produced by S. aureus during an infection are well characterized. However, some particular features could be observed in DFI. The aim of this review is to describe the role of S. aureus in DFI and the implication of its toxins in the establishment of the infection. Studies on this issue have helped to distinguish two S. aureus populations in DFI: toxinogenic S. aureus strains (harboring exfoliatin-, EDIN-, PVL- or TSST-encoding genes) and non-toxinogenic strains. Toxinogenic strains are often present in infections with a more severe grade and systemic impact, whereas non-toxinogenic strains seem to remain localized in deep structures and bone involving diabetic foot osteomyelitis. Testing the virulence profile of bacteria seems to be a promising way to predict the behavior of S. aureus in the chronic wounds.