Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
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DOI：
10.1155/2019/3741294
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发表时间：
2019-07-25
影响因子：
2.2
通讯作者：
Byakika-Kibwika, Pauline
中科院分区：
文献类型：
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作者：
Baluku, Joseph Baruch;Nassozi, Sylvia;Byakika-Kibwika, Pauline
疟疾和结核病(TB)混合感染的流行率在这两种疾病负担沉重的国家并不是很确定。疟疾可能会损害结核病的控制，增加结核病患者的死亡率。这项研究的目的是确定乌干达国家结核病治疗中心经细菌学确诊的成人结核病患者中疟疾/结核病合并感染的流行率。采用横断面研究设计，我们招募了363名细菌学确诊的成年结核病患者，并收集了人口统计学和病史的数据。对血样进行疟疾血涂片、疟疾快速诊断试验(RDT)、全血细胞计数、血液学涂片分析、HIV血清学以及CD4+和CD8+细胞计数。疟疾被定义为血涂片阳性或RDT。研究参与者大多为男性(61.4%)，年龄中位数为31岁(四分位数范围，IQR：25-39)，35.8%为HIV阳性。总体疟疾患病率为2.2%(8/363)，在对利福平耐药的参与者中为5%(3/58)。在3名参与者中观察到艾滋病毒、疟疾和利福平耐药结核病的三重感染。结核病患者中疟疾的流行率很低，有必要进一步评估这两种疾病的流行病学、临床和免疫学相互作用。
The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted.