Gender differences in brain reserve -: An 18F-FDG PET study in Alzheimer's disease
Gender differences in brain reserve -: An 18F-FDG PET study in Alzheimer's disease
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DOI：
10.1007/s00415-007-0558-z
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发表时间：
2007-10-01
影响因子：
6
通讯作者：
Kurz, Alexander
中科院分区：
文献类型：
--
作者：
Perneczky, Robert;Drzezga, Alexander;Kurz, Alexander
背景神经病理学研究表明，女性神经退行性脑损伤与临床症状之间的相关性可能比男性更强。目的验证在临床疾病严重程度相同的情况下，由神经退行性变引起的脑代谢缺陷在男性比女性更明显的假设。方法93例轻度阿尔茨海默病(AD)患者，男50例，女43例，在大学认知障碍门诊接受了广泛的临床和神经心理学检查及F-18-FDG PET显像。对每个研究组进行协方差分析(以年龄、CERAD神经心理测试总分和学校教育年限为协变量)，以确定糖代谢的性别差异。结果控制了年龄、教育程度和临床严重程度，确定了皮质区，男性的葡萄糖代谢显著低于女性。这些区域位于典型的受AD病理影响的区域(右下额叶、上颞叶和岛叶皮质，以及海马体)。结论这些数据表明，与女性相比，临床上相同严重程度的痴呆症患者中，男性的大脑代谢下降程度更大，这表明男性的大脑储备程度更高。
Background Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men. Objective To test the hypothesis that cerebral metabolic deficits due to neurodegeneration are more pronounced in men than in women at the same level of clinical disease severity. Methods 93 patients with mild Alzheimer's disease (AD; 50 men, 43 women) underwent an extensive clinical and neuropsychological examination and F-18-FDG PET imaging at a university-based outpatient unit for cognitive disorders. An analysis of covariance (with age, total score of the CERAD neuropsychological battery, and years of school education as covariates) was conducted in each study group to identify gender differences in glucose metabolism. Results Controlling for age, education, and clinical severity, cortical regions were identified,where glucose metabolism was significantly reduced in men as compared with women. These regions were located in areas typically affected by AD pathology (right inferior frontal, superior temporal and insular cortex, and hippocampus). Conclusions These data suggest that the same clinical severity of dementia is associated with greater reductions in cerebral metabolism in men than in women suggesting a greater degree of brain reserve in men.