Small solid pseudopapillary tumor of the pancreas in a 32-year-old man: Report of a case
Small solid pseudopapillary tumor of the pancreas in a 32-year-old man: Report of a case
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DOI：
10.1007/s00595-009-4139-x
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发表时间：
2010-08-01
期刊：
影响因子：
2.5
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Mima, Kosuke;Hirota, Masahiko;Baba, Hideo
胰腺实性假乳头状瘤(SPT)是一种罕见的肿瘤，主要发生在年轻女性。我们在此报告一例无症状的32岁男性胰头小SPT的病例，并复习文献。一位32岁的男性因胰腺肿块而住进熊本大学医院的我科。肿瘤中央有坏死，CT增强扫描呈低灌注性，磁共振T2加权像呈高信号。组织学显示病变为胰腺实性假乳头状肿瘤，具有特征性的假乳头形成和中央变性。然而，没有观察到胶囊的形成。CD56、CD10、α1-抗胰凝乳素、β-连环素和孕激素受体阳性。然而，肿瘤的胰腺激素、嗜铬粒蛋白-A、癌胚抗原和碳水化合物抗原19-9均为阴性。根据这些组织学发现，我们诊断患者有SPT。由于CT和MRI的最新进展，胰腺的小型实性假乳头状肿瘤越来越被人们所认识。我们也应该考虑SPT，即使它发生在男性，当肿瘤含有可疑的坏死区，而这些区域在T2加权MRI上高强度的对比增强CT上灌注度低。
A solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm that mainly occurs in young women. We herein report the case of a small SPT arising from the head of the pancreas in an asymptomatic 32-year-old man, plus a literature review of this tumor. A 32-year-old man was admitted to our department at Kumamoto University Hospital for the evaluation of a pancreatic mass. The tumor had central necrosis, which was poorly perfused on contrast-enhanced computed tomography (CT) and which had a high intensity on T2-weighted magnetic resonance imaging (MRI). Histology revealed the lesion to be a solid pseudopapillary tumor of the pancreas, with the characteristic pseudopapilla formation and central degeneration. However, no capsule formation was observed. The tumor was positive for CD56, CD10, alpha 1-antitrypsin, alpha 1-antichymotrypsin, beta-catenin, and progesterone receptor. However, the tumor was negative for pancreatic hormones, chromogranin-A, carcinoembryonic antigen, and carbohydrate antigen 19-9. We diagnosed the patient to have an SPT based on these histological findings. Small-sized solid pseudopapillary tumors of the pancreas are being increasingly recognized because of the recent advances in CT and MRI. We should also consider SPT even if it occurs in a male when the tumor contains necrosis-suspected areas which are poorly perfused on contrast-enhanced CT with a high intensity on T2-weighted MRI.