Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank
Cognitive ability and risk of death from lower respiratory tract infection: findings from UK Biobank
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DOI：
10.1038/s41598-018-38126-w
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发表时间：
2019-02-04
影响因子：
4.6
通讯作者：
Batty, G. David
中科院分区：
文献类型：
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作者：
Gale, Catharine R.;Deary, Ian J.;Batty, G. David
痴呆症会增加下呼吸道感染的风险，但目前还不清楚风险是否在认知能力的正常范围内变化。认知能力较高的人在下呼吸道感染的风险因素方面往往表现得更健康，有证据表明，他们整体上死于呼吸道疾病的风险较低。因此，我们调查了认知能力和下呼吸道感染死亡率之间的关系。参与者来自英国生物银行的434，413人（54%为女性）。认知能力的测量采用反应时间和推理测试。下呼吸道感染死亡数据来自死亡证明。在平均6.99年的随访期间，有1，282人死于下呼吸道感染。下呼吸道感染的死亡率随着认知能力的提高而下降。对于标准差更快的反应时间，年龄和性别调整的风险比（95%置信区间）为0.80（0.76，0.83），多变量调整的风险比为0.87（0.83，0.91）。当用推理测试评估认知能力时，也有类似的联系，尽管联系较弱。这些发现表明，认知能力在正常范围内的变化会增加死于下呼吸道感染的风险。
Dementia increases the risk of lower respiratory tract infection, but it is unclear whether risk varies across the normal range of cognitive ability. People with higher cognitive ability tend to behave in a healthier fashion as regards risk factors for lower respiratory tract infection and there is evidence that they have a lower risk of dying from respiratory disease as a whole. We therefore investigated the relationship between cognitive ability and mortality from lower respiratory tract infection. Participants were 434,413 people from UK Biobank (54% female). Cognitive ability was measured using tests of reaction time and reasoning. Data on deaths from lower respiratory infection were obtained from death certificates. Over a mean follow-up period of 6.99 years, 1,282 people died of lower respiratory infection. Mortality from lower respiratory tract infection fell as cognitive ability increased. For a standard deviation faster reaction time, the age- and sex-adjusted hazard ratio (95% confidence interval) was 0.80 (0.76, 0.83) and the multivariable-adjusted hazard ratio was 0.87 (0.83, 0.91). There were similar though weaker associations when cognitive ability was assessed using a reasoning test. These findings suggest that variation across the normal range of cognitive ability increase risk of dying from lower respiratory tract infection.