Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
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DOI：
10.1001/archinte.166.3.315
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发表时间：
2006-02-13
影响因子：
--
通讯作者：
Lloyd-Jones, DM
中科院分区：
文献类型：
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作者：
Januzzi, JL;Sakhuja, R;Lloyd-Jones, DM
背景：氨基末端脑钠素原(NT-proBNP)可用于呼吸困难患者的诊断和分流，但其预测预后的作用尚不明确。方法：前瞻性研究599例急诊呼吸困难患者，采集血样进行NT-proBNP检测。结果：1年后，91例患者(15.2%)死亡。死亡患者发病时NT-proBNP浓度中位数显著高于存活者(3277pg/ml比299pg/mL；P
Background: Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for diagnosis and triage of patients with dyspnea, but its role for predicting outcomes in such patients remains undefined.Methods: A total of 599 breathless patients treated in the emergency department were prospectively enrolled, and a sample of blood was obtained for NT-proBNP measurements. After 1 year, the vital status of each patient was ascertained, and the association between NT-proBNP values at presentation and mortality was assessed.Results: At 1 year, 91 patients (15.2%) had died. Median NT-proBNP concentrations at presentation among decedents were significantly higher than those of survivors (3277 vs 299 pg/mL; P