Anticonvulsant activity of embelin isolated from Embelia ribes
Anticonvulsant activity of embelin isolated from Embelia ribes
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DOI：
10.1016/j.phymed.2010.04.002
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发表时间：
2011-01-15
期刊：
影响因子：
7.9
通讯作者：
Badami, S.
中科院分区：
文献类型：
--
作者：
Mahendran, S.;Thippeswamy, B. S.;Badami, S.
灯盏花素(2.5、5、10 mg/kg)的抗惊厥作用对其进行了研究。对电休克和戊四氮所致惊厥有明显的抑制作用，且呈剂量依赖关系，其作用与苯妥英钠和安定相当。运动明显减少，显示其中枢抑制活性。研究结果表明，恩贝林对大发作和小发作癫痫均有抗惊厥作用。(C)2010年爱思唯尔股份有限公司。版权所有。
Anticonvulsant activity of embelin (2.5, 5 and 10 mg/kg, i.p.) was studied. It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam. Significant decrease in locomotion revealing its CNS depressant activity was observed. The findings suggest that embelin possess anticonvulsant activity against both grand mal and petit mal epilepsy. (C) 2010 Elsevier GmbH. All rights reserved.