Normal-pressure hydrocephalus: White matter lesions correlate negatively with gait improvement after lumbar puncture
Normal-pressure hydrocephalus: White matter lesions correlate negatively with gait improvement after lumbar puncture
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DOI：
10.1016/j.clineuro.2007.07.012
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发表时间：
2007-11-01
影响因子：
1.9
通讯作者：
Alves, Luisa
中科院分区：
文献类型：
--
作者：
Bugalho, Paulo;Alves, Luisa
目的：为了测试正常压力脑积水（NPH）患者的白色病变（WML）负荷与基线时步态特征、症状持续时间、腰椎穿刺（LP）后步态改善、血管危险因素之间的关系，Patients：15名特发性NPH patients.Methods：患者在LP之前和之后进行了定时步行试验。评估五个步态变量，并计算改善百分比。使用简单的视觉量表，在T2加权MRI图像中对WML负荷进行区域和全局评级。斯皮尔曼或皮尔逊相关系数被用来测试变量之间的关系。结果：WML评分和步态改善CSF去除后，但不与LP前的症状或步态变量的持续时间显着负相关。结论：WML似乎有助于NPH症状的不可逆性，但不是导致他们的病理生理机制。(C)2007 Elsevier B.V.保留所有权利。
Objectives: To test relations between white matter lesions (WML) load in Normal Pressure Hydrocephalus (NPH) patients and gait characteristics at baseline, duration of symptoms, gait improvement after lumbar puncture (LP), vascular risk factors.Patients: Fifteen idiopathic NPH patients.Methods: Patients underwent a timed walking test, before and after LP. Five gait variables were assessed and improvement percentages were calculated. WML load was rated regionally and globally in T2 weighted MRI images, using a simple visual scale. Spearman or Pearson correlation coefficients were used to test relations between variables.Results: Significant negative correlations were found between WML scores and gait improvement after CSF removal but not with duration of symptoms or gait variables before LP.Conclusions: WML seem to contribute to the irreversibility of symptoms in NPH but not to the pathophysiological mechanisms that lead to them. (C) 2007 Elsevier B.V. All rights reserved.