Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease
Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease
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DOI：
10.1002/gps.1435
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发表时间：
2006-02-01
影响因子：
4
通讯作者：
Pasqualetti, P
中科院分区：
文献类型：
--
作者：
Dal Forno, G;Chiovenda, P;Pasqualetti, P
目的验证意大利版本的电话采访认知状态（I-TICS）。方法电话管理的I-TICS 6周内的面对面测试与迷你精神状态检查（MMSE），在可能的阿尔茨海默病（AD）患者和健康对照。从University Campus BioMedico的痴呆症诊所招募了207名连续的认知障碍门诊患者。其中，分析了45例具有完整数据的可能AD患者。排除其他痴呆、轻度认知障碍（MCI）和数据不完整的患者。对照样本由64名年龄和性别匹配的健康受试者组成。诊断，广泛的临床评估，实验室测试，脑成像，脑电图，神经心理电池和抑郁量表。结果I-TICS与MMSE呈高度线性相关（Pearson 'sr = 0.904），I-TICS与MMSE呈显著正相关（Pearson' sr = 0.904）。提供了转换方程。两种测试的灵敏度和特异性相似（I-TICS的曲线下面积= 0.894; MMSE为0.966）。在截止值为28时，I-TICS的敏感性为84%，特异性为86%。MMSE的准确性无显著差异。I-TICS和MMSE之间的总一致率为86%（Cohen K = 0.717）。在一个亚组的患者中重复测试显示疾病进展相关的I-TICS评分下降4.2分/年（t = 2.664; p = 0.018.Conclusion I-TICS是一种有效的工具，在临床和研究中的AD筛查和监测。在其他痴呆和MCI中的潜在应用值得进一步研究。版权所有（c）2006约翰威利父子有限公司。
Objectives Validation of an Italian version of the Telephone Interview for Cognitive Status (I-TICS).Methods Telephone administration of the I-TICS within 6 weeks of face-to-face testing with the Mini Mental State Examination (MMSE), in Probable Alzheimer's disease (AD) patients and healthy controls. Two hundred and seven consecutive outpatients with cognitive impairment were recruited from Dementia Clinic of University Campus BioMedico. Of these, 45 probable AD patients with complete data were analyzed. Other dementias, Mild Cognitive Impairment (MCI), and patients with incomplete data were excluded. The control sample consisted of 64 age- and sex-matched healthy subjects. For diagnosis, an extensive clinical evaluation, laboratory testing, brain imaging, EEG, neuropsychological battery and a depression scale were used. For I-TICS validation, telephone I-TICS and face-to-face MMSE were administered.Results The I-TICS correlated highly and linearly with the MMSE (Pearson's r = 0.904). Conversion equations are provided. Sensitivity and specificity were similar between tests (area under curve = 0.894 for the I-TICS; 0.966 for the MMSE). I-TICS sensitivity was 84% and specificity 86% at a cut-off score of 28. No significant difference in accuracy with the MMSE was present. Total agreement between I-TICS and MMSE was 'substantial' at 86% (Cohen's K = 0.717). Repeated testing in a subset of patients showed a disease progression related decrease of 4.2 points/year (t = 2.664; p = 0.018) in I-TICS scores.Conclusion The I-TICS is a valid instrument in clinical and research screening and monitoring of AD. Potential applications in other dementias and MCI are worth further studies. Copyright (c) 2006 John Wiley & Sons, Ltd.