Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart
Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart
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DOI：
10.1016/j.ejphar.2007.09.034
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发表时间：
2008-01-28
影响因子：
5
通讯作者：
Dehpour, Ahmad Reza
中科院分区：
文献类型：
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作者：
Hajrasouliha, Amir Reza;Tavakoli, Sina;Dehpour, Ahmad Reza
除了众所周知的神经行为效应外，内源性大麻素还发挥多种心血管作用。最近，它们被认为可以保护心肌免受缺血/再灌注损伤。本研究的目的是研究内源性大麻素对远程缺血预处理提供的心脏保护的贡献。三组远程预处理（肠系膜动脉闭塞15分钟，然后再灌注15分钟）和三组假手术大鼠包括在研究中。在远程预处理或假手术前15 min，动物静脉内预处理溶剂、大麻素CB 1（AM 251，1 mg/kg）或CB 2（AM 630，1 mg/kg）受体拮抗剂。冠状动脉闭塞30分钟，再灌注2小时，诱导心肌损伤。比较各组间的动脉低血压、室性心律失常和梗死面积。远程预处理具有明显的心肌保护作用，表现为心肌梗死面积显著减小（P
In addition to well-known neurobehavioral effects, endogenous cannabinoids exert diverse cardiovascular actions. Recently, they have been suggested to protect the myocardium, against ischemia,/reperfusion injury. The aim of this study is to examine the contribution of endogenous cannabinoids to cardioprotection afforded by remote ischemic preconditioning. Three groups of remote preconditioned (15 min of mesenteric artery occlusion followed by 15 min of reperfusion) and three groups of sham-operated rats were included in the study. Animals were pretreated intravenously by vehicle, cannabinoid CB1 (AM251, 1 mg/kg) or CB2 (AM630, 1 mg/kg) receptor antagonist 15 min prior to remote preconditioning or sham operation. Myocardial injury was induced by 30 min of coronary artery occlusion followed by 2 h of reperfusion. The resultant arterial hypotension, ventricular arrhythmias, and infaret size were compared among the groups. Remote preconditioning exerted potent cardioprotection manifested as significant reductions in infarct size (P