Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight
复制标题
DOI：
10.1038/nn.2720
复制
发表时间：
2011-01-01
影响因子：
25
通讯作者：
Di Marzo, Vincenzo
中科院分区：
文献类型：
--
作者：
Di Marzo, Vincenzo
中枢神经系统内源性大麻素系统的研究主要集中在内源性大麻素受体和失活机制。直到最近，人们对内源性大麻素信号中生物合成酶的作用知之甚少。最近开发的用于研究这些酶的药理学和遗传工具的新数据表明，它们在确定内源性大麻素何时何地发挥作用方面发挥着根本作用，并提出了在内源性大麻素信号传导的一般策略中出现新的有趣且以前未被怀疑的概念的可能性。然而，即使有了这些新工具，花生四烯酸酰胺和2-花生四烯酸甘油生物合成之间的串扰也使得很难将两者分开，需要考虑到这一点来解释数据。
Studies of the endocannabinoid system in the CNS have been mostly focused on endocannabinoid receptors and inactivating mechanisms. Until recently, very little was known about the role of biosynthetic enzymes in endocannabinoid signaling. New data from the recent development of pharmacological and genetic tools for the study of these enzymes point to their fundamental role in determining where and when endocannabinoids function, and raise the possibility of new intriguing and previously unsuspected concepts in the general strategy of endocannabinoid signaling. However, even with these new tools, the cross-talk between anandamide and 2-arachidonoylglycerol biosynthesis makes it difficult to dissect one from the other, and data will need to be interpreted with this in mind.