Characteristics of local field potentials correlate with pain relief by deep brain stimulation
Characteristics of local field potentials correlate with pain relief by deep brain stimulation
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局部场电位的特征与深部脑刺激的疼痛缓解相关
DOI：
10.1016/j.clinph.2016.04.011
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发表时间：
2016-07-01
影响因子：
4.7
通讯作者：
Wang, Shouyan
中科院分区：
文献类型：
--
作者：
Huang, Yongzhi;Luo, Huichun;Wang, Shouyan
目的：探讨感觉丘脑和脑室周围灰质/导水管周围灰质（PVAG）的神经元活动与深部脑刺激（DBS）镇痛的关系。方法：记录10例神经性疼痛患者术后感觉丘脑和PVAG的局部场电位（lfp）。采用谱分析和时频分析量化lfp，采用非线性相关分析量化lfp与疼痛缓解的关系。结果：感觉丘脑和PVAG的θ波振荡与疼痛缓解呈负相关。感觉丘脑的高β振荡和PVAG的α振荡与疼痛缓解呈正相关。此外，感觉丘脑和PVAG中theta波段活动的高功率持续时间与低功率持续时间的比例与疼痛缓解呈负相关。感觉丘脑高β带的持续时间比与疼痛缓解呈正相关。结论：我们的研究结果揭示了不同的θ、α和β频率的神经元振荡与DBS疼痛缓解相关。意义：该研究为预测DBS缓解神经性疼痛的结果提供了定量方法，并为制定适应性刺激策略提供了潜在的生物标志物。(C) 2016年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To investigate the link between neuronal activity recorded from the sensory thalamus and periventricular gray/periaqueductal gray (PVAG) and pain relief by deep brain stimulation (DBS).Methods: Local field potentials (LFPs) were recorded from the sensory thalamus and PVAG post-operatively from ten patients with neuropathic pain. The LFPs were quantified using spectral and time-frequency analysis, the relationship between the LFPs and pain relief was quantified with nonlinear correlation analysis.Results: The theta oscillations of both sensory thalamus and PVAG correlated inversely with pain relief. The high beta oscillations in the sensory thalamus and the alpha oscillations in the PVAG correlated positively with pain relief. Moreover, the ratio of high-power duration to low-power duration of theta band activity in the sensory thalamus and PVAG correlated inversely with pain relief. The duration ratio at the high beta band in the sensory thalamus correlated positively with pain relief.Conclusions: Our results reveal distinct neuronal oscillations at the theta, alpha, and beta frequencies correlating with pain relief by DBS. Significance: The study provides quantitative measures for predicting the outcomes of neuropathic pain relief by DBS as well as potential biomarkers for developing adaptive stimulation strategies. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.