Neuroimaging in human dystonia.
Neuroimaging in human dystonia.
复制标题
DOI：
10.2152/jmi.52.272
复制
发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
--
作者：
Asanuma, Kotaro;Carbon-Correll, Maren;Eidelberg, David
功能性神经成像，如正电子发射断层扫描（PET）和功能性磁共振成像（fMRI），提供了一种有价值的技术，用于检测与人类疾病相关的脑代谢活动的区域变化。这些技术已被应用于不同的肌张力障碍，包括原发性全身性肌张力障碍和多巴反应性肌张力障碍（DRD），以及局灶性肌张力障碍综合征，如斜颈，书写痉挛，眼睑痉挛。一个常见的发现是基底神经节和相关的流出途径的感觉运动皮层和其他地区参与运动性能的异常。其他最近的成像研究已经利用基于扩散的MRI技术来定位肌张力障碍患者和基因携带者中的独特的微结构异常。本报告将集中在一个综合的方法来理解这种遗传和生化多样性疾病的病理生理学。
Functional neuroimaging, such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), provides a valuable technique for detecting regional changes in brain metabolic activity associated with human disease. These techniques have been applied in different dystonic disorders including primary generalized dystonia and dopa-responsive dystonia (DRD), as well as focal dystonic syndromes such as torticollis, writer's cramp, and blepharospasm. A common finding is abnormality of the basal ganglia and associated outflow pathways to sensorimotor cortex and other regions involved with motor performance. Other recent imaging research has utilized diffusion-based MRI techniques to localize distinct microstructural abnormalities in dystonia patients and gene carriers. This presentation will focus on an integrated approach to understanding the pathophysiology of this genetic and biochemically diverse disorder.