Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma
Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma
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DOI：
10.1016/s0304-3835(02)00590-6
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发表时间：
2003-02-20
期刊：
影响因子：
9.7
通讯作者：
Kuwano, M
中科院分区：
文献类型：
--
作者：
Saji, H;Toi, M;Kuwano, M
耐药性是癌症治疗中常见的临床问题。 P-糖蛋白的过度表达似乎与抗癌药物的多药耐药性密切相关。 YB-1 与 MDR1 启动子区域的 Y 盒结合，编码 P-糖蛋白。我们评估了 63 例人类乳腺癌中核 YB-1 和 P-糖蛋白表达与其他分子（例如激素受体、血管生成因子、免疫因子和金属蛋白酶）之间的相关性。核YB-1表达与P-糖蛋白和PgR表达显着相关，并且还与CD68等级显着相关，涉及肿瘤相关巨噬细胞的积累。该系列并未证明 P-糖蛋白和核 YB-1 表达可能是乳腺癌有用的预后标志物之一。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Drug resistance is a common clinical problem in cancer treatment. The overexpression of P-glycoprotein appears to be closely associated with multi-drug resistance to anticancer agents. YB-1 binds to the Y-box in the promoter region of MDR1, which encodes P-glycoprotein. We evaluated the correlation between nuclear YB-1 and P-glycoprotein expression and other molecules, such as hormonal receptors, angiogenic factors, immune factors, and methalloprotease in 63 human breast cancers. Nuclear YB-1 expression had a significant correlation with P-glycoprotein and PgR expression, and also with CD68 grade, concerning accumulation of tumor associated macrophages. This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.