Glycosylation pathways at the ocular surface.
Glycosylation pathways at the ocular surface.
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DOI：
10.1042/bst20170408
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发表时间：
2018-04-17
影响因子：
3.9
通讯作者：
Argüeso P
中科院分区：
文献类型：
--
作者：
Rodriguez Benavente MC;Argüeso P
糖基化是有机分子的一种主要的酶促修饰形式，在生物体中参与多种生物过程。多糖的生物合成受一系列糖基转移酶、糖苷酶和糖链修饰酶的控制，这些酶共同组装和处理单糖部分形成不同的结构。许多研究已经深入了解了眼表糖基化的各种途径，如与粘蛋白O-糖链和N-糖链在蛋白质上的生物合成有关的途径，但许多其他途径仍然很大程度上仍不清楚。本文综述了眼表面所描述的不同类型的葡聚糖，重点介绍了它们的生物合成途径和生物学相关性。准确了解生理和病理条件下的这些通路有助于识别生物标记物和治疗干预的新靶点。
Glycosylation is a major form of enzymatic modification of organic molecules responsible for multiple biological processes in an organism. The biosynthesis of glycans is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying enzymes that collectively assemble and process monosaccharide moieties into a diverse array of structures. A number of studies have provided insight into various pathways of glycosylation at the ocular surface, such as those related to the biosynthesis of mucin-type O-glycans and N-glycans on proteins, but many others still remain largely unknown. This review provides an overview of the different classes of glycans described at the ocular surface focusing on their biosynthetic pathways and biological relevance. A precise understanding of these pathways under physiological and pathological conditions could help identify biomarkers and novel targets for therapeutic intervention.