SERUM CONCENTRATIONS OF LAMININ AND AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN IN RELATION TO THE PORTAL VENOUS-PRESSURE OF FIBROTIC LIVER-DISEASES
SERUM CONCENTRATIONS OF LAMININ AND AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN IN RELATION TO THE PORTAL VENOUS-PRESSURE OF FIBROTIC LIVER-DISEASES
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DOI：
10.1016/0009-8981(86)90008-2
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发表时间：
1986-12-30
影响因子：
5
通讯作者：
PICKKOBER, KH
中科院分区：
文献类型：
--
作者：
GRESSNER, AM;TITTOR, W;PICKKOBER, KH
在纤维化肝病患者（n = 33）的血清中，在组织学上分为不同程度的肝纤维化（n = 21）和肝硬化（n = 12）的基底膜蛋白层粘连蛋白和其胃蛋白酶抗性片段P1和III型前胶原的N-末端前肽的浓度进行了测定。这两种蛋白质的浓度与这些患者中测量的门静脉压力相关。与参考群体（n = 146）相比，层粘连蛋白的浓度从1.04U/ml（正常人）增加到1.69 ± 0.5U/ml。0.46肝纤维化组为2.58 ± 0.05U/ml; 0.87 U/ml。虽然III型前胶原的前肽浓度增加，但血清中两种结缔组织蛋白之间仅存在弱相关性。门静脉高压症患者门静脉压力与层粘连蛋白呈高度正相关（r = 0.9206），层粘连蛋白升高程度与门静脉高压程度密切相关。几乎所有层粘连蛋白浓度在参考范围内的纤维化患者门静脉压力正常。这些数据表明，层粘连蛋白作为一个潜在的有用参数监测门静脉压力在肝硬化和严重纤维化患者。
In sera of patients with fibrotic liver diseases (n = 33) classified histologically into various degrees of liver fibrosis (n = 21) and cirrhosis (n = 12) the concentrations of the basement membrane protein laminin and of its pepsinresistant fragment P1 and of the N-terminal propeptide of type III procollagen were determined. The concentrations of both proteins were related to the portal venous pressure measured in these patients. Compared with the reference population (n = 146) the concentration of laminin increases from 1.04 U/ml (normal persons) to 1.69 .+-. 0.46 U/ml in liver fibrotic and 2.58 .+-. 0.87 U/ml in liver cirrhotic patients. Although the concentrations of the propeptide of type III procollagen increase also there exist only weak correlations between both connective tissue proteins in serum. Laminin is correlated highly positive with the portal venous pressure in cirrhotic subjects (r = 0.9206), the extent of laminin elevation reflects closely the degree of portal hypertension. Virtually all of the fibrotic patients having a laminin concentration within the reference range had a normal portal venous pressure. The data suggest laminin as a potentially useful parameter for monitoring the portal venous pressure in cirrhotic and severe fibrotic patients.