Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy
Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy
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DOI：
10.1016/j.ijrobp.2005.12.043
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发表时间：
2006-06-01
影响因子：
7
通讯作者：
Sun, Xiao-Feng
中科院分区：
文献类型：
--
作者：
Wallin, Asa R.;Svanvik, Joar;Sun, Xiao-Feng
目的：PRL-3（肝再生磷酸酶）参与结直肠癌的转移;然而，尚未研究其在癌症患者中的治疗意义。我们研究了直肠癌患者中PRL表达与放射治疗（RT）的关系。用免疫组化法检测了36例远端正常粘膜、82例邻近正常粘膜、125例原发性肿瘤、96例活检组织中再生肝磷酸酶的表达，结果：再生肝磷酸酶在直肠癌组织中的表达从远处到癌旁粘膜和原发灶逐渐增强（p < 0.05）。PRL在28%的原发灶和26%的转移灶的浸润边缘高表达。在RT组中，浸润边缘的PRL强表达与远处复发（p = 0.006）和生存率差（p = 0.01）相关，但在非RT组中则无关。即使在调整Dukes分期和分化后，生存率仍有显著性（p = 0.02）。另外的多变量分析显示，与PRL的预后意义的相关性在RT组和非RT组之间不同（p = 0.01）。结论：在浸润边缘再生肝表达的磷酸酶（而不是单独的PRL-3）预测了术前RT的直肠癌患者对RT的抵抗和不利的生存。
Purpose: PRL-3 (phosphatase of regenerating liver) is involved in metastasis of colorectal cancer; however, its therapeutic implication in cancer patients has not been studied. We investigated the relationships of PRL expression to radiotherapy (RT) in rectal cancer patients.Methods and Materials: Phosphatase of regenerating liver expression was immunohistochemically examined in distant (n = 36) and adjacent (n = 82) normal mucosa, primary tumor (n = 125), biopsy specimens (n = 96), and lymph node metastasis (n = 30) from rectal cancer patients participating in a clinical trial of preoperative RT.Results: Phosphatase of regenerating liver expression was increased from the distant to adjacent mucosa and to the primary tumor (p < 0.05). PRL was highly expressed at the invasive margin in 28% of the primary tumors and 26% of the metastases. In the RT group, strong PRL expression at the invasive margin was related to distant recurrence (p = 0.006) and poor survival (p = 0.01), but not in the non-RT group. The survival significance remained even after adjusting for Dukes' stage and differentiation (p = 0.02). Additional multivariate analyses showed that the correlation with prognostic significance of PRL differed between the RT and non-RT groups (p = 0.01).Conclusion: Phosphatase of regenerating liver expression (rather than PRL-3 alone) at the invasive margin predicted resistance to RT and unfavorable survival in rectal cancer patients with preoperative RT. (c) 2006 Elsevier Inc.