Association between toenail scandium levels and risk of acute myocardial infarction in European men:: the EURAMIC and Heavy Metals Study
Association between toenail scandium levels and risk of acute myocardial infarction in European men:: the EURAMIC and Heavy Metals Study
复制标题
DOI：
10.1191/0748233702th156oa
复制
发表时间：
2002-01-01
影响因子：
1.9
通讯作者：
Fernández-Crehuet, J
中科院分区：
文献类型：
--
作者：
Gómez-Aracena, J;Martin-Moreno, JM;Fernández-Crehuet, J
在欧洲和以色列的10个中心进行的一项多中心病例对照研究中，对钪状态与急性心肌梗死（MI）风险之间的关系进行了研究。对684例70岁以下的患者和724例对照者的趾甲进行了钪含量测定。病例组和对照组的趾甲钪平均浓度分别为6.74 μ g/kg和7.75 mg/kg。对照组中，调整年龄和中心钪与脂肪组织中番茄红素和油酸的浓度呈正相关（两种营养素P = 0.002）。经年龄和中心校正后，钪与番茄红素（r = 0.08）、锌（r = 0.08）、汞（r = 0.18）和油酸（r = 0.21）之间的Pearson相关性显著（P < 0.05）。总体而言，在调整年龄和中心后，病例的钪水平低于对照组（病例对照比，0.87; 95%CI 0.79-0.96）。在调整其他心血管危险因素后，这种相关性仍然存在（病例对照比0.88; 95%CI，0.79-0.98）。校正年龄和中心后，高钪水平下MI的风险降低（P趋势= 0.04）。进一步调整BMI、高血压史、吸烟、饮酒、糖尿病、CHD家族史、α-生育酚、β-胡萝卜素、番茄红素、硒和汞略微减弱了这一趋势（P = 0.055）。我们的研究结果表明，趾甲钪水平与急性心肌梗死的风险降低有关，但我们不确定这种元素是否真的可以在冠心病的发展中发挥保护作用。在没有确定合理机制的情况下，这些结果应被视为初步结果，并应在未来的研究中进行测试。
The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 mug/kg in cases and 7.75 mg/kg in controls. Scandium among controls, adjusted for age and centre was positively associated with concentrations of lycopene and oleic acid in adipose tissue (P = 0.002 for both nutrients). Pearson correlations adjusted for age and centre were significant (P < 0.05) between scandium and lycopene (r = 0.08), zinc (r = 0.08), mercury (r = 0.18) and oleic acid (r = 0.21). Overall, cases had lower levels of scandium than controls after adjustment for age and centre ( case control ratio, 0.87; 95% CI 0.79-0.96). This association persisted after adjustment for other cardiovascular risk factors (case-control ratio 0.88; 95% CI, 0.79-0.98). The risk of MI at high scandium levels was reduced after adjustment for age and centre (P-trend = 0.04). Further adjustments for BMI, history of hypertension, smoking, alcohol intake, diabetes, family history of CHD, alpha-tocopherol, beta-carotene, lycopene, selenium and mercury slightly attenuated this trend (P = 0.055). Our results suggest that toenail scandium level is associated with a reduced risk of acute MI, but we are uncertain whether this element can really play a protective role in the development of CHD. Without an identified plausible mechanism, these results should be regarded as preliminary and should be tested in future studies.