Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission
Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission
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DOI：
10.1111/j.1749-6632.1998.tb10192.x
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发表时间：
1998-01-01
期刊：
影响因子：
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通讯作者：
De Montigny, C
中科院分区：
文献类型：
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作者：
Blier, P;Piñeyro, G;De Montigny, C
控制5-羟色胺（5-HT）在整个脑中释放的一个非常重要的元件是存在于5-HT神经元的索马和树突上的5-HT 1A自身受体，因为它对它们的放电活动施加负反馈影响。在用选择性5-HT再摄取抑制剂（SSRI）治疗开始时，该5-HT 1A自身受体受到内源性5-HT的增加的激活，因此，获得降低的5-HT神经元放电活性。随着SSRI治疗时间的延长，5-HT 1A自身受体脱敏，并且在SSRI存在下放电活动恢复。这种适应性变化至少部分地是SSRI在重性抑郁症中的延迟治疗效果的基础，这得到了5-HT 1A自身受体拮抗剂吲哚洛尔与SSRI同时给药加速抗抑郁反应的支持。
A very important element controlling serotonin (5-HT) release throughout the brain is the 5-HT1A autoreceptor present on the soma and dendrites of 5-HT neurons since it exerts a negative feedback influence on their firing activity, This 5-HT1A autoreceptor receives an increased activation by endogenous 5-HT at the beginning of a treatment with a selective 5-HT reuptake inhibitor (SSRI) and, consequently, a decreased 5-HT neuronal firing activity is obtained. As the SSRI treatment is prolonged, the 5-HT1A autoreceptor desensitizes and firing activity is restored in the presence of the SSRI, That this adaptive change underlies, at least in part, the delayed therapeutic effect of SSRI in major depression is supported by the acceleration of the antidepressant response by the concomitant administration of the 5-HT1A autoreceptor antagonist pindolol with SSRIs.