The effect of partial denervation of tibialis anterior (TA) muscle on the number and sizes of motorneurons in TA motornucleus of normal and dystrophic (C57BL dy2j/dy2j) mice.
The effect of partial denervation of tibialis anterior (TA) muscle on the number and sizes of motorneurons in TA motornucleus of normal and dystrophic (C57BL dy2j/dy2j) mice.
复制标题
胫骨前肌 (TA) 肌肉部分去神经对正常和营养不良 (C57BL dy2j/dy2j) 小鼠 TA 运动核中运动神经元数量和大小的影响。
DOI：
10.1139/y91-261
复制
发表时间：
1991
影响因子：
2.1
通讯作者：
D. Parry
中科院分区：
文献类型：
--
作者：
H. Tissenbaum;D. Parry
通过切除部分外侧腘神经，使正常（C57 BL）和营养不良（dy2j）小鼠的一条腿的胫骨前肌（TA）部分失神经支配。两个月后，肌肉被注射辣根过氧化物酶，以允许幸存的运动神经元的可视化。C57和dy 2 j小鼠的部分去神经导致为肌肉提供能量的运动神经元数量减少至正常补充量的大约一半。存活的运动神经元被发现是显着大于（约25%），比他们的对侧同行。这种情况持续长达18个月，不被认为是对与部分去神经相关的创伤的短暂反应。当目标组织的大小也减少了一半的TA连同部分去神经切除，运动神经元的大小没有发现增加。有人建议，在大小的增加是对运动神经元的代谢需求的反应，运动单位的大小增加。
The tibialis anterior (TA) muscle in one leg of normal (C57BL) and dystrophic (dy2j) mice was partially denervated by resection of a part of the lateral popliteal nerve. Two months later the muscle was injected with horseradish peroxidase to permit visualization of the motorneurons that survived. Partial denervation in both C57 and dy2j mice resulted in reduction of the number of motorneurons that supplied the muscle to approximately one-half the normal complement. The surviving motorneurons were found to be significantly larger (about 25%) than their contralateral counterparts. This condition persisted up to 18 months and is not considered to be a transient response to the trauma associated with the partial denervation. When the size of the target tissue was also reduced by extirpation of one-half of TA together with partial denervation, motorneuron size was not found to increase. It is suggested that the increase in size is a response to the metabolic demands placed upon the motorneuron by an increase in the size of the motor unit.