Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes.
Association between human papillomavirus infection and common sexually transmitted infections, and the clinical significance of different Mycoplasma subtypes.
复制标题
人乳头瘤病毒感染与共同性传播感染之间的关联，以及不同支原体亚型的临床意义。
DOI：
10.3389/fcimb.2023.1145215
复制
发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
人乳头瘤病毒（HPV）感染，尤其是持续性高危型HPV感染，与宫颈癌相关。女性生殖道微生态失调和下生殖道感染与HPV感染及宫颈病变的关联日益密切。由于存在共同的危险因素和传播途径，HPV与其他性传播感染（STIs）的合并感染已成为一个关注点。此外，支原体亚型的临床意义似乎各不相同。本研究旨在评估常见性传播感染与HPV感染之间的相关性，并探究支原体亚型的临床意义。
我们招募了2021年3月至2022年2月期间于北京大学第一医院妇科门诊进行宫颈癌筛查且同时接受阴道炎和宫颈炎检测的1175名患者。所有患者均接受了HPV基因分型检测和性传播感染检测，其中749名患者接受了阴道镜检查和宫颈活检。
结果发现，HPV阳性组中需氧菌性阴道炎/脱屑性炎症性阴道炎及性传播感染（主要为单一性传播感染）的发生率显著高于HPV阴性组。在单一性传播感染患者中，HPV阳性组的2型单纯疱疹病毒或解脲脲原体UP6感染率显著高于HPV阴性组（校正比值比：1.810，95%置信区间：1.211 - 2.705，P = 0.004；校正比值比：11.032，95%置信区间：1.465 - 83.056，P = 0.020）。
通过详细的支原体分型，发现不同支原体亚型与HPV感染之间存在相关性。这些研究结果表明，对于HPV阳性者，应更加关注检测其阴道微生态失调情况。此外，HPV阳性女性中，包括阴道感染和宫颈性传播感染在内的下生殖道感染明显更为常见，因此需要更全面的检测。在临床实践中，对支原体进行详细分型和针对性治疗应更为常规化。
Human papillomavirus (HPV) infection, especially persistent high-risk HPV, is associated with cervical cancer. Female reproductive tract microecological disorders and lower genital tract infections have been increasingly correlated with HPV infection and cervical lesions. Due to their common risk factors and transmission routes, coinfection with other sexually transmitted infections (STIs) has become a concern. Additionally, the clinical significance of Mycoplasma subtypes appear to vary. This study aimed to assess the correlations between common STIs and HPV infection, and to investigate the clinical significance of Mycoplasma subtypes. We recruited 1,175 patients undergoing cervical cancer screening at the Peking University First Hospital gynecological clinic from March 2021 to February 2022 for vaginitis and cervicitis tests. They all received HPV genotyping and detection of STIs, and 749 of them underwent colposcopy and cervical biopsy. Aerobic vaginitis/desquamative inflammatory vaginitis and STIs (mainly single STIs) were found significantly more often in the HPV-positive group than in the HPV-negative group. Among patients with a single STI, rates of infection with herpes simplex virus type 2 or UP6 in the HPV-positive group were significantly higher than in the HPV-negative group (ORadj: 1.810, 95%CI: 1.211–2.705, P=0.004; ORadj: 11.032, 95%CI: 1.465–83.056, P=0.020, respectively). Through detailed Mycoplasma typing, a correlation was found between different Mycoplasma subtypes and HPV infection. These findings suggest that greater attention should be paid to detecting vaginal microecological disorders in those who are HPV-positive. Further, lower genital tract infections, including both vaginal infections and cervical STIs, are significantly more common among women who are HPV-positive and who thus require more thorough testing. Detailed typing and targeted treatment of Mycoplasma should become more routine in clinical practice.
登录
查看更多内容
影响因子：
3.4
作者：
Ma X;Wu M;Wang C;Li H;Fan A;Wang Y;Han C;Xue F
通讯作者：
Xue F
影响因子：
7.2
作者：
Bornstein, Jacob;Bentley, James;Walker, Patrick
通讯作者：
Walker, Patrick
影响因子：
5.7
作者：
通讯作者：
--
DOI：
10.31557/apjcp.2021.22.4.1239
发表时间：
2021-04-01
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
--
作者：
Noma IHY;Shinobu-Mesquita CS;Suehiro TT;Morelli F;De Souza MVF;Damke E;Da Silva VRS;Consolaro MEL
通讯作者：
Consolaro MEL
影响因子：
3.8
作者：
Li S;Wen X
通讯作者：
Wen X