Measurement of hemodynamic changes with the axial flow blood pump installed in descending aorta
Measurement of hemodynamic changes with the axial flow blood pump installed in descending aorta
复制标题
降主动脉轴流血泵测量血流动力学变化
DOI：
10.1007/s10047-017-0985-2
复制
发表时间：
2017
影响因子：
1.3
通讯作者：
Mitamura Y
中科院分区：
文献类型：
--
作者：
Okamoto E;Yano T;Miura H;Shiraishi Y;Yambe T;Mitamura Y
我们开发了各种轴流血泵来实现Valvo泵的概念，并且我们研究了使用与自然心脏串联的轴流血泵在心脏辅助下的血流动力学变化。在这项研究中，我们在急性动物实验中使用放置在降主动脉中的最新轴流血泵，不仅测量了体循环的血流动力学变化，还测量了心脏支持下的脑循环和冠脉循环。通过对山羊（43.8 kg，雌性）进行左胸廓切开术将轴流血泵安装在胸降主动脉处。当泵开启时，泵下游的主动脉压力和主动脉流量随着脉动的保留而增加。泵上游的压降导致后负荷压力降低，并且可能导致左心室壁应力降低。然而，当泵开启时，脑血流量和冠状血流量减少。轴流式血泵能够更有效地将血液灌注到体循环中，但存在脑循环和冠脉循环血液灌注障碍的潜在风险。结果表明，冠状动脉口前的位置可能适合于与自然心脏串联的轴流血泵植入，以避免血液灌注障碍。
We have developed various axial flow blood pumps to realize the concept of the Valvo pump, and we have studied hemodynamic changes under cardiac assistance using an axial flow blood pump in series with the natural heart. In this study, we measured hemodynamic changes of not only systemic circulation but also cerebral circulation and coronary circulation under cardiac support using our latest axial flow blood pump placed in the descending aorta in an acute animal experiment. The axial flow blood pump was installed at the thoracic descending aorta through a left thoracotomy of a goat (43.8 kg, female). When the pump was on, the aortic pressure and aortic flow downstream of the pump increased with preservation of pulsatilities. The pressure drop upstream of the pump caused reduction of afterload pressure, and it may lead to reduction of left ventricular wall stress. However, cerebral blood flow and coronary blood flow were decreased when the pump was on. The axial flow blood pump enables more effective blood perfusion into systemic circulation, but it has the potential risk of blood perfusion disturbance into cerebral circulation and coronary circulation. The results indicate that the position before the coronary ostia might be suitable for implantation of the axial flow blood pump in series with the natural heart to avoid blood perfusion disturbances.