Evolution of the initiating enzymes of the complement system.
Evolution of the initiating enzymes of the complement system.
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DOI：
10.1186/gb-2001-3-1-reviews1001
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发表时间：
2002
期刊：
影响因子：
12.3
通讯作者：
Miyazawa S
中科院分区：
文献类型：
--
作者：
Nonaka M;Miyazawa S
对编码凝集素触发的补体级联的两种蛋白酶的人MASP-1/3基因的分析已经揭示了该基因的两种蛋白质产物的交替使用的丝氨酸蛋白酶编码区。系统发育研究表明，在脊椎动物进化的早期通过逆转录转座而产生，支持补体级联的凝集素分支比“经典”途径更早出现的观点。
Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway.