Diffusion-weighted MR imaging in patients with phenylketonuria: Relationship between serum phenylalanine levels and ADC values in cerebral white matter
Diffusion-weighted MR imaging in patients with phenylketonuria: Relationship between serum phenylalanine levels and ADC values in cerebral white matter
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DOI：
10.1148/radiol.2362040611
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发表时间：
2005-08-01
期刊：
影响因子：
19.7
通讯作者：
Inoue, Y
中科院分区：
文献类型：
--
作者：
Kono, K;Okano, Y;Inoue, Y
目的：前瞻性地确定苯丙酮尿症(PKU)患者血清苯丙氨酸水平与脑白质表观扩散系数(ADC)值之间的关系。材料和方法：获得机构评审委员会的批准，参与者提供知情同意。对21例PKU患者进行磁共振(MR)检查，包括T1加权、T2加权、液体衰减反转恢复(FLAIR)和弥散加权成像。计算每个患者大脑深部白质的ADC值。所有患者均在磁共振成像后12天内测定血清苯丙氨酸水平。16例患者在磁共振成像前一年测量了血清苯丙氨酸水平。比较脑白质ADC值和血清苯丙氨酸水平。共21例对照受试者(男12例，女9例；年龄3-33岁，平均20.6岁)接受了MRI检查。结果：血清苯丙氨酸>8.5 mg/dL(514.2 mU/L)的PKU患者在T2加权像和FLAIR像上表现为脑白质异常高信号。当MR成像后检测到血清苯丙氨酸水平升高时，患者大脑后深层白质的弥散倾向于受到限制(r=-0.62)。脑白质ADC值与磁共振成像前1年测得的血清苯丙氨酸水平呈负相关(r=-0.77)。对照组ADC显著高于PKU患者组(P
PURPOSE: To prospectively determine the relationship between serum phenylalanine levels and apparent diffusion coefficient (ADC) values in the cerebral white matter of patients with phenylketonuria (PKU).MATERIALS AND METHODS: Institutional review board approval was obtained, and participants provided informed consent. Magnetic resonance (MR) imaging, which included T1- and T2-weighted, fluid-attenuated inversion-recovery (FLAIR), and diffusion-weighted examinations, was performed in 21 patients with PKU (nine male and 12 female patients; age range, 3-44 years; mean age, 19.4 years). ADC values in deep cerebral white matter were calculated for each patient. Serum phenylalanine levels were-obtained in all patients within 12 days after MR imaging. Serum phenylalanine levels were measured in 16 patients I year before MR imaging. ADC values in cerebral white matter and serum phenylalanine levels were compared. A total of 21 control subjects (12 male and nine female patients; age range, 3-33 years; mean age, 20.6 years) underwent MR imaging. ADC values in cerebral white matter were compared with serum phenylalanine levels by using the Pearson correlation.RESULTS: Abnormal high signal intensity in white matter on T2-weighted and FLAIR MR images was noted in patients with PKU who had serum phenylalanine levels of more than 8.5 mg/dL (514.2 mu mol/L). Diffusion in posterior deep cerebral white matter tended to be restricted in patients when increased serum phenylalanine levels were measured after MR imaging (r = -0.62). There was a correlation between ADC values in posterior cerebral white matter and serum phenylalanine levels measured I year before MR imaging (r = -0.77). ADCs of control subjects were significantly higher than ADCs of patients with PKU (P