THE ACTION OF PLANT EXTRACTS ON A BACTERIOPHAGE OF PSEUDOMONAS-PYOCYANEA AND ON INFLUENZA-A VIRUS
THE ACTION OF PLANT EXTRACTS ON A BACTERIOPHAGE OF PSEUDOMONAS-PYOCYANEA AND ON INFLUENZA-A VIRUS
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DOI：
10.1099/00221287-6-1-2-74
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发表时间：
1952-01-01
期刊：
影响因子：
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通讯作者：
PYLE, AH
中科院分区：
文献类型：
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作者：
CHANTRILL, BH;COULTHARD, CE;PYLE, AH
研究了288种植物的提取物对绿脓杆菌噬菌体发育的抑制作用，其中大部分为英国植物。许多具有这种特性，其中8种抑制噬菌体生长的浓度低于影响宿主Ps生长的浓度的十分之一。pyocyanea。对142种植物的提取物进行了抗甲型流感病毒的胚胎卵试验，其中12种提取物抑制了病毒的增殖。所有抗甲型流感病毒的提取物对噬菌体也有活性。在小鼠身上测试的四种抗甲型流感提取物没有活性。对8种提取物进行了进一步的研究；它们被蛋白质灭活，只有在无蛋白质的培养基中与病毒直接接触时才有活性，活性与提取物的单宁含量密切相关，不能从单宁中分离出来。商业单宁在无蛋白质培养基中也非常活跃。
Extracts of 288 plants, mostly British, were examined for suppressive action on the development of a bacteriophage ofPseudomonas pyocyanea. Many possessed this property and eight of them suppressed the growth of phage at concentrations less than one-tenth of those which affected the growth of the host,Ps. pyocyanea.Extracts from 142 of the plants were tested against Influenza A virus in embryonated eggs and twelve of them suppressed virus multiplication. All extracts active against Influenza A virus were also active against the bacteriophage. Four extracts tested against Influenza A in mice were inactive. Eight extracts were investigated further; these were inactivated by proteins and were only active when in direct contact with the virus in protein-free media, Activity was closely associated with the tannin content of the extracts and could not be separated from it. Commercial tannins were also highly active in protein-free media.