Effects of the population pedigree on genetic signatures of historical demographic events
Effects of the population pedigree on genetic signatures of historical demographic events
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DOI：
10.1073/pnas.1601080113
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发表时间：
2016-07-19
影响因子：
11.1
通讯作者：
Wilton, Peter R.
中科院分区：
文献类型：
--
作者：
Wakeley, John;King, Leandra;Wilton, Peter R.
二倍体双亲生物体基因组中基因座之间的遗传变异是通过该物种的系谱或种群系谱进行突变和遗传传递的结果。我们探讨了这对两种人口统计事件的无关联基因座变异模式的影响：非常大的家庭的发生或最近发生的强选择性扫荡。结果表明，只有相当极端的这类事件才能以这样一种方式构建群体谱系，即无关联的基因座将显示出与群体遗传学标准预测的偏差，后者是群体谱系的平均值。结果还表明，个体和基因座的大样本增加了获得这些事件特征的机会，而且非常大的家庭可能在突变等位基因的样本分布方面具有独特的特征。
Genetic variation among loci in the genomes of diploid biparental organisms is the result of mutation and genetic transmission through the genealogy, or population pedigree, of the species. We explore the consequences of this for patterns of variation at unlinked loci for two kinds of demographic events: the occurrence of a very large family or a strong selective sweep that occurred in the recent past. The results indicate that only rather extreme versions of such events can be expected to structure population pedigrees in such a way that unlinked loci will show deviations from the standard predictions of population genetics, which average over population pedigrees. The results also suggest that large samples of individuals and loci increase the chance of picking up signatures of these events, and that very large families may have a unique signature in terms of sample distributions of mutant alleles.