Cellular pathophysiology of ischemic acute kidney injury
Cellular pathophysiology of ischemic acute kidney injury
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DOI：
10.1172/jci45161
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发表时间：
2011-11-01
影响因子：
15.9
通讯作者：
Yang, Li
中科院分区：
文献类型：
--
作者：
Bonventre, Joseph V.;Yang, Li
缺血性肾损伤通常发生在多器官衰竭和脓毒症的情况下。在这里，我们回顾了这一动态过程的主要组成部分，其中涉及血流动力学改变、炎症以及内皮和上皮细胞损伤，然后进行适应性修复并恢复上皮完整性或适应不良，从而导致慢性肾脏疾病。更好地了解肾损伤和修复背后的细胞病理生理过程将有望设计出更有针对性的治疗方法，以预防损伤、加速修复并最大限度地减少慢性进行性肾病。
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.