BIDIRECTIONAL SELECTION FOR SUSCEPTIBILITY TO ETHANOL WITHDRAWAL SEIZURES IN MUS-MUSCULUS
BIDIRECTIONAL SELECTION FOR SUSCEPTIBILITY TO ETHANOL WITHDRAWAL SEIZURES IN MUS-MUSCULUS
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DOI：
10.1007/bf01065448
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发表时间：
1985-11-01
影响因子：
2.6
通讯作者：
MCSWIGAN, JD
中科院分区：
文献类型：
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作者：
CRABBE, JC;KOSOBUD, A;MCSWIGAN, JD
通过从遗传异质性的HS/Ibg小鼠群体中进行家族内选择，选择了高（戒断性癫痫易感性；WSP）和低（戒断性癫痫抗性；WSR）对慢性乙醇暴露后抽搐的易感性。还维持了两条非选择控制线（收回-扣押控制；WSC）。在11代的重复实验中，反应是双向的，WSP系和WSR系在相同的慢性乙醇暴露方案后，癫痫发作的严重程度相差约10倍。实现遗传率约为0.28。表型在本质上似乎是多基因的。这些品系近亲交配的数量相对较少，对选择的反应较大，这应该有助于研究对乙醇的生理依赖的生理基础。
Using within-family selection from a genetically heterogeneous population of HS/Ibg mice, lines and replicates have been selected for high (withdrawal seizure prone; WSP) and low (withdrawal seizure resistant; WSR) susceptibility to convulsions after withdrawal from chronic exposure to ethanol. Two nonselected control lines (withdrawal-seizure control; WSC) have also been maintained. The response was bidirectional in both replicates across 11 selected generations, WSP and WSR lines differing approximately 10-fold in seizure severity after an identical regimen of chronic exposure to ethanol. Realized heritability was found to be approximately 0.28. The phenotype appears to be polygenic in nature. The relatively low amount of inbreeding in these lines and the large response to selection should make them useful for examining the physiological basis of physical dependence on ethanol.