Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy
Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy
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DOI：
10.1097/01.yct.0000263257.44539.23
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发表时间：
2007-03-01
期刊：
影响因子：
2.5
通讯作者：
Holsinger, Tracey
中科院分区：
文献类型：
--
作者：
Goforth, Harold W.;Holsinger, Tracey
重度抑郁障碍是一种难于治疗的反复发作的衰弱障碍。到目前为止，所有被批准的针对重度抑郁症的躯体治疗在显示抗抑郁效果之前都需要相当长的时间。然而，新出现的证据表明，使用氯胺酮可能会迅速缓解严重抑郁症的症状。我们报告一例严重的、复发性的严重抑郁障碍，在接受术前剂量的氯胺酮和双颞叶电极放置的电惊厥治疗后的8小时内有显著改善。这一案例支持了氯胺酮在迅速和安全地缓解严重抑郁障碍症状方面的作用。
Major depressive disorder is a difficult-to-treat and recurrent debilitating disorder. All approved somatic treatments for major depression to date require a significant time lapse before demonstrating an antidepressant effect. However, emerging evidence indicates a potential role for the use of ketamine to rapidly relieve symptoms of major depression. We present a case of severe, recurrent major depressive disorder that demonstrated marked improvement within 8 hours of receiving a preoperative dose of ketamine and I treatment of electroconvulsive therapy with bitemporal electrode placement. This case is supportive of a role of ketamine in relieving symptoms of major depressive disorder rapidly and safely.