Radiofrequency heat-enhanced direct intratumoral chemotherapy for prostate cancer.
Radiofrequency heat-enhanced direct intratumoral chemotherapy for prostate cancer.
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前列腺癌的射频热增强直接瘤内化疗。
DOI：
10.3892/ol.2017.7145
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发表时间：
2017-12
期刊：
影响因子：
2.9
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Wu X;Zhang F;Hu P;Chen L;Han G;Bai W;Luo J;Chen R;Zhou Y;Sun J;Yang X
射频热（RFH）是一种新的微创介入技术，可提高实体器官肿瘤的化疗疗效。然而，前列腺癌的治疗尚未完全表征。本研究的目的是探讨化疗联合射频消融治疗前列腺癌的体外和体内效率。包括以下四个治疗组：i）无治疗（对照）; ii）仅RFH; iii）仅化疗（多西他赛）;和iv）多西他赛和RFH在人前列腺癌（HPC）细胞系和具有HPC异种移植物的小鼠中的联合治疗。在体外实验中，将加热导丝连接到四腔室细胞培养载玻片的最后一个腔室的底部，然后连接到射频（RF）发生器。在体内实验中，通过将人前列腺癌细胞皮下注射到24只雄性nu/nu小鼠中产生肿瘤模型。通过将0.022英寸加热导丝插入肿瘤中进行RFH。随访的磁共振成像显示，与仅接受RFH和仅接受化疗的动物相比，联合治疗的动物的平均肿瘤大小显著减小。联合治疗组的凋亡细胞数和平均凋亡指数明显高于其他三个治疗组。总之，本研究的结果表明，RFH能够增加多西他赛在前列腺癌中的治疗效率，并且本研究为将来开发一种介入分子图像引导的前列腺癌局部治疗策略奠定了基础，该策略整合了RF技术，介入肿瘤学和直接瘤内化疗，作为全身化疗的替代品。
A novel, minimally invasive interventional technique, radiofrequency heat (RFH), has been suggested to improve the efficacy of chemotherapy for solid organ tumors. However, the treatment for prostate cancer has not been completely characterized. The aim of the present study was to investigate the in vitro and in vivo efficiency of chemotherapy in combination with RFH for the treatment of prostate cancer. The following four treatment groups were included: i) No treatment (control); ii) RFH-only; iii) chemotherapy (docetaxel)-only; and iv) combination therapy of docetaxel and RFH in human prostate cancer (HPC) cell lines and mice with HPC xenografts. In the in vitro experiments, a heating guidewire was attached under the bottom of the last chamber of the four-chamber cell culture slide, and was then connected to a radiofrequency (RF) generator. In the in vivo experiments, a tumor model was generated by subcutaneously injecting human prostate cancer cells into 24 male nu/nu mice. RFH was conducted by inserting the 0.022-inch heating-guidewire into the tumor. The follow-up magnetic resonance imaging demonstrated a significant reduction in the average tumor size in animals treated with combination therapy compared with those receiving RFH-only and chemotherapy-only. The number of apoptotic cells and the average apoptotic index of the combination therapy group were significantly higher compared with those of the other three treatment groups. In conclusion, the results of the present study suggested that RFH is able to increase the therapeutic efficiency of docetaxel in prostate cancer, and this study serves as a foundation for the future development of an interventional molecular image-guided local treatment strategy for prostate cancer that integrates RF technology, interventional oncology and direct intratumoral chemotherapy, as a replacement for systemic chemotherapy.
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影响因子：
3.2
作者：
Serpa Neto, Ary;Tobias-Machado, Marcos;Del Giglio, Auro
通讯作者：
Del Giglio, Auro
影响因子：
19.7
作者：
Zhang, Feng;Le, Thomas;Yang, Xiaoming
通讯作者：
Yang, Xiaoming
影响因子：
2.9
作者：
Wei, Zhigang;Ye, Xin;Han, Xiaoying
通讯作者：
Han, Xiaoying
DOI：
10.1126/science.1171362
发表时间：
2009-06-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Olive KP;Jacobetz MA;Davidson CJ;Gopinathan A;McIntyre D;Honess D;Madhu B;Goldgraben MA;Caldwell ME;Allard D;Frese KK;Denicola G;Feig C;Combs C;Winter SP;Ireland-Zecchini H;Reichelt S;Howat WJ;Chang A;Dhara M;Wang L;Rückert F;Grützmann R;Pilarsky C;Izeradjene K;Hingorani SR;Huang P;Davies SE;Plunkett W;Egorin M;Hruban RH;Whitebread N;McGovern K;Adams J;Iacobuzio-Donahue C;Griffiths J;Tuveson DA
通讯作者：
Tuveson DA
影响因子：
2.9
作者：
Zhang, Tong;Zhang, Feng;Meng, Yanfeng;Wang, Han;Le, Thomas;Wei, Baojie;Lee, Donghoon;Willis, Patrick;Shen, Baozhong;Yang, Xiaoming
通讯作者：
Yang, Xiaoming