Dependence Receptors: The Trophic Theory Revisited
Dependence Receptors: The Trophic Theory Revisited
复制标题
DOI：
10.1126/scisignal.3151pe47
复制
发表时间：
2010-12-07
影响因子：
7.3
通讯作者：
Mehlen, Patrick
中科院分区：
文献类型：
--
作者：
Mehlen, Patrick
大多数跨膜受体被认为在不存在其同源配体的情况下是无活性的，并且仅在配体结合时启动下游信号转导。然而，研究表明，一些受体在没有配体的情况下也具有活性，并诱导“负”信号来触发细胞凋亡。因此，这些被称为依赖性受体的受体产生了对配体可用性的依赖的细胞状态。依赖性受体理论假设这些受体在胚胎发育、神经退行性疾病或癌症进展和转移过程中发挥关键作用，并得到了新证据的支持。
Most transmembrane receptors are believed to be inactive in the absence of their cognate ligand and initiate downstream signal transduction only upon ligand binding. However, research has shown that some receptors are also active in the absence of their ligand and induce a "negative" signal to trigger apoptosis. Thus, these receptors, dubbed dependence receptors, create a cellular state of dependence on ligand availability. The dependence receptor theory postulates key roles for these receptors during embryonic development, neurodegenerative diseases, or cancer progression and metastasis, and is bolstered by new evidence.