HIV incidence and factors associated with HIV acquisition among injection drug users in St Petersburg, Russia
HIV incidence and factors associated with HIV acquisition among injection drug users in St Petersburg, Russia
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DOI：
10.1097/01.aids.0000218555.36661.9c
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发表时间：
2006-04-04
期刊：
影响因子：
3.8
通讯作者：
Hoffman, IF
中科院分区：
文献类型：
--
作者：
Kozlov, AP;Shaboltas, AV;Hoffman, IF
背景：俄罗斯HIV-1的流行是由注射吸毒引起的。目的：确定艾滋病毒感染率，确定感染的人口统计学和行为学相关因素，以促进艾滋病毒纵向预防计划的发展。方法：2002年在俄罗斯圣彼得堡招募520名注射吸毒者（IDU）进行HIV-1检测和咨询。纳入hiv血清阴性的IDU并在6个月和12个月时重新评估。在每次研究访问期间进行艾滋病毒检测，并收集社会人口统计学和行为数据。评估社会人口学和行为因素与HIV-1发病率的关系。结果：大多数入组受试者为年轻男性，住在家里，受过教育，海洛因使用者，经常共用针头和其他注射用具。在12个月的随访中，保留率为80%。HIV-1感染率为4.5/100人年。在单变量分析中，精神兴奋剂的使用，特别是频繁使用，过去6个月内有3个或更多的性伴侣，以及女性性交易与HIV血清转化有关。在多变量分析中，每周使用三次或三次以上的精神兴奋剂是仍然与HIV血清转化相关的唯一因素。结论：圣彼得堡艾滋病毒感染率高，是欧洲注射药物集中流行最严重的地区之一。针对精神兴奋剂和海洛因使用者及其伴随行为（如频繁注射和性活动增加）的干预措施是迫切需要的。(C) 2006 Lippincott Williams & Wilkins。
Background: The Russian HIV-1 epidemic has been driven by injection drug use.Objective: To determine HIV incidence and identify demographic and behavioral correlates of infection to facilitate the development of longitudinal HIV prevention programs.Methods: In 2002, a cohort of 520 injection drug users (IDU) in St Petersburg, Russia were recruited and tested and counseled for HIV-1. HIV-seronegative IDU were enrolled and reevaluated at 6 and 12 months. HIV testing was performed and sociodemographic and behavioral data were collected during each study visit. The relationship of sociodemographic and behavioral factors to HIV-1 incidence was assessed.Results: Most enrolled subjects were young, male, living at home, educated, heroin users, and frequently shared needles and other injection paraphernalia. The retention rate at the 12 month follow-up was 80%. The HIV-1 incidence rate was 4.5/100 person-years. In univariate analysis, psychostimulant use, especially frequent use, three or more sex partners in the past 6 months, and females selling sex were associated with HIV seroconversion. In the multivariate analysis, psychostimulant use three or more times per week was the only factor still associated with HIV seroconversion.Conclusions: The high incidence of HIV infection places St Petersburg among the worst IDU-concentrated epidemics in Europe. Interventions targeting psychostimulant and heroin users and their accompanying behaviors such as frequent injections and increased sexual activity are needed immediately. (C) 2006 Lippincott Williams & Wilkins.