The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients
The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients
复制标题
ANxA6基因多态性对银屑病患者甲氨蝶呤治疗疗效的影响
DOI：
10.1159/000514072
复制
发表时间：
2021-02-12
期刊：
影响因子：
3.4
通讯作者：
Yan, Kexiang
中科院分区：
文献类型：
--
作者：
Fan, Zhijia;Zhang, Zhenghua;Yan, Kexiang
Background: There are great interindividual variations in the clinical efficacy of methotrexate (MTX) treatment and patients' genetic background seems promising in its explanation. Objectives: The study aimed to test whether the polymorphism of annexin A6 (ANxA6) gene, a susceptibility factor for psoriasis, was associated with the clinical response to MTX therapy. Methods: A total of 325 patients enrolled in the study received oral MTX treatment, of whom 310 completed the 1-year study and performed the genotype analysis. They were defined as responders (a reduction of Psoriasis Area and Severity Index [PASI] score >= 75%) and nonresponders (a reduction of PASI
