Sex hormones and skeletal muscle weakness
Sex hormones and skeletal muscle weakness
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DOI：
10.1007/s10522-013-9425-8
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发表时间：
2013-06-01
期刊：
影响因子：
4.5
通讯作者：
Kovanen, Vuokko
中科院分区：
文献类型：
--
作者：
Sipila, Sarianna;Narici, Marco;Kovanen, Vuokko
人类衰老伴随着内分泌功能的退化，其中最显著和最明显的是性激素的产生减少。目前的研究文献表明，低性激素浓度可能是肌肉减少症和肌肉无力的关键机制之一。在欧洲大规模MYOAGE项目中，进一步研究了性激素、雌激素和睾酮在引起与衰老相关的肌肉质量和功能损失中的作用。女性激素替代疗法（HRT）被证明可以减少与年龄相关的肌肉损失，快速肌肉功能（力量）的损失和骨骼肌中脂肪的积累。此外，HRT提高了抗阻训练后骨骼肌中的蛋白质合成速率，并对骨骼肌和肌腱中的结缔组织具有合成代谢作用，从而影响基质结构和机械性能。HRT影响例如细胞骨架和细胞基质蛋白中的基因表达，对IGF-I具有刺激作用，并且在IL-6和脂肪因子调节中起作用。尽管循环中类固醇激素水平较低，但绝经后妇女骨骼肌中类固醇生成酶的局部浓度较高。
Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within the European large scale MYOAGE project, the role of sex hormones, estrogens and testosterone, in causing the aging-related loss of muscle mass and function was further investigated. Hormone replacement therapy (HRT) in women is shown to diminish age-associated muscle loss, loss in fast muscle function (power), and accumulation of fat in skeletal muscle. Further HRT raises the protein synthesis rate in skeletal muscle after resistance training, and has an anabolic effect upon connective tissue in both skeletal muscle and tendon, which influences matrix structure and mechanical properties. HRT influences gene expression in e.g. cytoskeletal and cell-matrix proteins, has a stimulating effect upon IGF-I, and a role in IL-6 and adipokine regulation. Despite low circulating steroid-hormone level, postmenopausal women have a high local concentration of steroidogenic enzymes in skeletal muscle.