Heteroannulation enabled by a bimetallic Rh(iii)/Ag(i) relay catalysis: application in the total synthesis of aristolactam BII.
Heteroannulation enabled by a bimetallic Rh(iii)/Ag(i) relay catalysis: application in the total synthesis of aristolactam BII.
复制标题
DOI：
10.1039/c7cc02105d
复制
发表时间：
2017-05
影响因子：
4.9
通讯作者：
Wei-Wei Ji-Wei;E. Lin;Qingjiang Li;Honggen Wang
中科院分区：
文献类型：
--
作者：
Wei-Wei Ji-Wei;E. Lin;Qingjiang Li;Honggen Wang
氧化还原中性的Rh（iii）/Ag（i）接力催化允许有效地构建3-亚烷基异吲哚啉酮和3-亚烷基异苯并呋喃酮。Rh（iii）催化剂负责C-H单氟烯基化反应，而Ag（i）盐是后续环化的活化剂。所开发的方法学应用于天然产物马兜铃内酰胺BII的快速全合成的关键步骤。
A redox-neutral bimetallic Rh(iii)/Ag(i) relay catalysis allowed the efficient construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The Rh(iii) catalyst was responsible for the C-H monofluoroalkenylation reaction, whereas the Ag(i) salt was an activator for the follow-up cyclization. The methodology developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.