Chemo‐Catalyzed Pathways to Lactic Acid and Lactates
Chemo‐Catalyzed Pathways to Lactic Acid and Lactates
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DOI：
10.1002/adsc.201600768
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发表时间：
2016-12
影响因子：
5.4
通讯作者：
I. Shuklov;N. Dubrovina;K. Kühlein;A. Börner
中科院分区：
文献类型：
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作者：
I. Shuklov;N. Dubrovina;K. Kühlein;A. Börner
乳酸是生产可生物降解聚合物（PLLA、PDLA等）的重要组成部分。以及制药工业的起始原料。目前这种手性化合物的生产主要是发酵法。然而，在过去的三十年里，许多可用于生产乳酸的催化反应被开发出来。与发酵相比，高反应速率和简单的产物分离是许多这些过程的特征。可获得高达99%ee的优异立体选择性。本文综述了利用催化剂合成对映体纯的和外消旋的乳酸和乳酸酯的化学方法。分析了这些工艺的效率和经济性。
Lactic acid is an important building block for the production of biodegradable polymers (PLLA, PDLA, etc.) as well as starting material for the pharmaceutical industry. The current production of this chiral compound is dominated by fermentation processes. However many catalytic reactions that could be used for manufacturing lactic acid were developed in the past three decades. High reaction rates and simple separation of products in comparison to fermentation characterize many of these processes. Excellent stereoselectivities up to 99% ee could be achieved. This review aims to give a critical overview of chemical processes applying catalysis as an alternative for the production of both enantiomerically pure and racemic lactic acid and lactates. The efficiency and economy of these processes are analyzed.