EFFECTS OF SEX-HORMONES ON DEVELOPMENT OF PHYSIOLOGICAL AND PATHOLOGICAL CARDIAC-HYPERTROPHY IN MALE AND FEMALE RATS
EFFECTS OF SEX-HORMONES ON DEVELOPMENT OF PHYSIOLOGICAL AND PATHOLOGICAL CARDIAC-HYPERTROPHY IN MALE AND FEMALE RATS
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DOI：
10.1152/ajpheart.1990.259.3.h866
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发表时间：
1990-09-01
影响因子：
--
通讯作者：
SCHEUER, J
中科院分区：
文献类型：
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作者：
MALHOTRA, A;BUTTRICK, P;SCHEUER, J
先前的研究已经证明了性激素在维持大鼠正常心脏重量和肌球蛋白同工酶平衡中的作用。为了确定性激素是否是引起心脏适应游泳或高血压慢性负荷所必需的，雌性大鼠被切除性腺（X），然后暴露于慢性游泳程序（Sw）或肾性高血压8-10周。由于雌性动物的性腺切除增加了心脏和体重，因此纳入了单独的食物限制久坐和Sw性腺切除雌性动物（XFR）组。在雌性对照组（C）、X和XFR中，游泳导致心脏重量和心室V1异肌球蛋白百分比显著增加。在C、X和X中研究了雌激素替代的高血压。在所有组中均出现心脏肥大，但雌激素治疗减弱了血压正常和高血压X动物中V1异肌球蛋白百分比的下降。游泳通常与雄性心脏肥大无关，但也在该性别中进行了研究。性腺切除术并没有改变心脏重量或肌球蛋白同工酶对Sw的反应，虽然睾酮替代性腺切除男性恢复心室V1肌球蛋白水平或高于正常。血清甲状腺水平和心肌儿茶酚胺的测量未能证明这些激素和各种结果之间的因果关系。因此，虽然性激素对维持大鼠正常心脏重量和肌球蛋白同工酶平衡很重要，但它们在心脏暴露于生理或病理负荷时表现出的适应性中似乎并不重要。
Previous studies have demonstrated a role for sex hormones in maintaining normal heart weight and myosin isoenzyme balance in the rat. To determine if sex hormones were necessary to elicit cardiac adaptations to the chronic loads of swimming or hypertension, female rats were gonadectomized (X) and then exposed either to a chronic swimming program (Sw) or to renal hypertension for 8-10 wk. Because gonadectomy in females increased heart and body weight, separate groups of food-restricted sedentary and Sw gonadectomized females (XFR) were included. Swimming resulted in significant increases in both heart weight and in the percent ventricular V1 isomyosin in female controls (C), X, and XFR. Hypertension was studied in C, X, and X with estrogen replacement. Cardiac hypertrophy developed in all groups, but estrogen therapy attenuated the decline in percent V1 isomyosin in both normotensive and hypertensive X animals. Swimming, which is generally not associated with cardiac hypertrophy in males, was also studied in that sex. Gonadectomy did not alter either the heart weight or the myosin isoenzyme response to Sw, although testosterone replacement in gonadectomized males restored ventricular V1 myosin levels to or above normal. Measures of serum thyroid levels and of myocardial catecholamines failed to demonstrate a causal relationship between these hormones and the various results. Therefore, although sex hormones are important for maintaining normal heart weights and myosin isoenzyme balance in rats, they do not appear to be important in the adaptations hearts exhibit when exposed to physiological or pathological loads.