Absence of Dynein Arms in Endometrial Cilia: Cause of Infertility?
Absence of Dynein Arms in Endometrial Cilia: Cause of Infertility?
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子宫内膜纤毛缺乏动力蛋白臂：不孕的原因？
DOI：
10.3109/00016348309156261
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发表时间：
1983
影响因子：
4.3
通讯作者：
H. Pedersen
中科院分区：
文献类型：
--
作者：
H. Pedersen
抽象的。自从证实不活动的人类精子中完全缺乏动力蛋白臂（2，10）以来，人们对慢性鼻窦炎和支气管症状患者鼻粘膜纤毛中纤毛亚结构的研究产生了相当大的兴趣。由于上述4例精子不动的患者中有3例存在胸部器官的位置倒置，因此认为Kartagener综合征的基本缺陷可能是类似的亚结构性纤毛缺陷。这一假设似乎得到了证实，在这些患者的鼻粘膜纤毛中缺乏动力蛋白臂（9）。
Abstract. Since the demonstration of a total lack of dynein arms in immobile human spermatozoa (2, 10) there has been considerable interest in the investigation of the ciliary substructure in nasal mucosa cilia in patients with chronic sinusitis and bronchial symptoms. Since 3 out of the 4 patients described above with immobile spermatozoa had situs inversus of the thoracic organs, it was thought that the basic defect in Kar‐tagener's syndrome might be a similar substructural ciliary defect. This hypothesis seemed to be confirmed by the demonstration of a lack of dynein arms in nasal mucosa cilia in such patients (9).