Low serum IgA and airway injury in World Trade Center-exposed firefighters: a 17-year longitudinal study.
Low serum IgA and airway injury in World Trade Center-exposed firefighters: a 17-year longitudinal study.
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暴露于世贸中心的消防员的低血清 IgA 和气道损伤：一项为期 17 年的纵向研究。
DOI：
10.1136/thoraxjnl-2019-213715
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发表时间：
2019
期刊：
影响因子：
10
通讯作者：
Weiden,MichaelD
中科院分区：
文献类型：
--
作者：
Putman,Barbara;Lahousse,Lies;Zeig-Owens,Rachel;Singh,Ankura;Hall,CharlesB;Liu,Yang;Schwartz,Theresa;Goldfarb,David;Webber,MayrisP;Prezant,DavidJ;Weiden,MichaelD
血清Ig A≤70 mg/dL(低Ig A)与慢性阻塞性肺疾病的加重有关。低IgA水平与纵向肺功能的关系尚不明确。这项研究包括917名暴露于世界贸易中心(WTC)的消防员，他们在2001年9月至2018年9月期间进行了纵向肺活量测定，并在2001年10月至2002年3月期间进行了IgA测定。与Ig A和Gt；70 mg/dL相比，低Ig A与2001年9月11日后预测的1 FEV1%的用力呼气量(FEV1%)降低(94.1%vs98.6%，p<；0.001)、增加FEV1/Fvc<；0.70(HR 3.8，95% CI 1.6~8.8)和增加抗生素治疗(22.5/100vs11.6/100人年，p=0.002)有关。暴露于世贸中心后，早期IgA≤70 /dL与肺功能恶化和抗生素治疗增加相关。
Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.