Temporal regulation of Stat5 activity in determination of cell differentiation program.
Temporal regulation of Stat5 activity in determination of cell differentiation program.
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Stat5 活性在细胞分化程序测定中的时间调节。
DOI：
10.1016/j.bbrc.2007.05.018
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发表时间：
2007
影响因子：
3.1
通讯作者：
Fujii,Hodaka
中科院分区：
文献类型：
--
作者：
Hoshino,Akemi;Fujii,Hodaka
虽然Stat 5被各种细胞因子激活，但只有促红细胞生成素（Epo）和少量细胞因子诱导Stat 5依赖性红细胞分化。在这里，通过使用报告基因系统来监测转录活性的Stat 5，我们表明，Epo，而不是白细胞介素（IL）-3支持持续激活Stat 5，诱导珠蛋白基因的表达。IL-3或IL-2刺激抑制Epo诱导的珠蛋白基因表达。IL-2受体β链的酸性区域对于这种抑制是必需的。这些结果强调了时间调节的Stat活性的调节的精氨酸特异性细胞分化的重要性。
Although Stat5 is activated by various cytokines, only erythropoietin (Epo) and a small number of cytokines induce Stat5-dependent erythroid differentiation. Here, by using a reporter gene system to monitor transcriptional activity of Stat5, we showed that Epo but not interleukin (IL)-3 supports sustained activation of Stat5, which induces globin gene expression. IL-3 or IL-2 stimulation inhibits Epo-induced globin gene expression. The acidic region of the IL-2 receptor β-chain was essential for this inhibition. These results underscore the importance of temporal regulation of Stat activity for regulation of cytokine-specific cell differentiation.