Red cell membranes, a methodological approach
Red cell membranes, a methodological approach
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红细胞膜，一种方法论方法
DOI：
10.1007/s00198-003-1465-5
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发表时间：
1982
影响因子：
4
通讯作者：
J. Young
中科院分区：
文献类型：
--
作者：
J. Ellory;J. Young
本增刊包含了一个研讨会的程序，旨在确定骨脆性的材料，细胞和结构基础。这次会议汇集了具有骨小梁和皮质宏观和微观结构，其无机，有机和细胞组成，骨建模和重塑，骨细胞分化和功能的局部和全身调节剂，细胞外基质蛋白，血管生成，机械转导机制，生物力学和遗传研究方面专业知识的研究人员。会议的目的是统一这些高度专业化的领域，指导每个主题对更好地了解骨脆性的发病机制。罗伯特希尼和罗伯特林赛分别讨论了骨重建的原则和药物治疗的现状。John Bilezikian讨论了代谢性骨病的骨质量，特别是原发性甲状旁腺功能亢进。骨的无机和有机组成与其强度的关系由John Currey讨论。Currey博士对比了矿物质、有机物和水含量比例的改变对骨组织硬度和韧性的影响。增加矿物质会增加骨组织的硬度，而减少胶原蛋白会降低骨材料的韧性。皮质骨中胶原对强度的贡献可能小于松质骨。
This supplement contains the proceedings of a workshop aimed at defining the material, cellular, and structural basis of bone fragility. This meeting brought together investigators with expertise in bone’s trabecular and cortical macroscopic and microscopic architecture, its inorganic, organic, and cellular composition, bone modeling and remodeling, the local and systemic regulators of bone cell differentiation and function, extracellular matrix proteins, angiogenesis, mechanisms of mechanotransduction, biomechanics, and genetic research. The purpose of the meeting was to unify these highly specialized areas by directing each topic toward a better understanding of the pathogenesis of bone fragility.The principles of bone remodeling and the current status of drug therapy are discussed by Robert Heaney and Robert Lindsay, respectively. John Bilezikian discusses bone quality in metabolic bone disease, in particular primary hyperparathyroidism. The inorganic and organic composition of bone in relation to its strength is discussed by John Currey. Dr. Currey contrasts the effects of alterations in the proportions of mineral, organic, and water content on the stiffness and toughness of bone tissue. Increasing mineral increases the stiffness of bone tissue, while decreasing collagen reduces the toughness of bone material. The contribution of collagen to strength may be less in cortical than in trabecular bone.