Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study
Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study
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DOI：
10.1093/aje/kwi066
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发表时间：
2005-03-01
影响因子：
5
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
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作者：
Kojima, M;Wakai, K;Tamakoshi, A
为了检验血清脂肪酸与结直肠癌风险的关系，作者对169例结直肠癌病例和481名按年龄和登记地区匹配的对照进行了嵌套病例对照研究，作为日本合作队列研究的一部分。血清样本由受试者在基线(1988年至1990年)时捐献，并在零下80摄氏度保存到2002年。用气相色谱仪测定血清脂肪酸水平，并用总脂肪重量百分比表示。调整生活方式因素的条件Logistic回归分析显示，总omega-3多不饱和脂肪酸(优势比=0.24，95%可信区间：0.08，0.76)，α-亚麻酸(优势比=0.39，95%可信区间：0.16，0.91)，二十二碳五烯酸(优势比=0.30，95%可信区间：0.11，0.80)，二十二碳六烯酸(优势比=0.23，95%可信区间：0.07，0.76)均显示男性结直肠癌四分位数水平最高者与最低者相比风险显著降低。对于女性，观察到二十二碳五烯酸与结直肠癌风险之间存在微弱的负相关，尽管这在统计学上并不显著。没有检测到高水平的omega-6多不饱和脂肪酸对结直肠癌风险的不利影响。
To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80degreesC until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.