Metabolic pancreatitis: Etiopathogenesis and management.
Metabolic pancreatitis: Etiopathogenesis and management.
复制标题
DOI：
10.4103/2230-8210.117208
复制
发表时间：
2013-09
影响因子：
--
通讯作者：
Modi KD
中科院分区：
文献类型：
--
作者：
Kota SK;Krishna SV;Lakhtakia S;Modi KD
急性胰腺炎是一种医学急症。酒精和胆结石是最常见的病因，占病例的60%-75%。其他重要原因包括内窥镜后逆行胰胆管造影术、腹部创伤、药物毒性、各种感染、自身免疫性、缺血和遗传性原因。在大约15%的病例中，原因仍然未知（特发性胰腺炎）。引起胰腺炎的代谢性疾病不太常见，占5%-10%的病例。其原因包括高胆固醇血症、高钙血症、糖尿病、卟啉症和威尔逊氏病。胰腺炎的发作往往更加严重。在代谢性胰腺炎的情况下，除了胰腺炎的标准常规管理之外，对潜在的代谢异常进行仔细管理至关重要。如果治疗不当，它会导致反复发作的危及生命的急性胰腺炎。现就代谢性胰腺炎的发病机制及治疗作一综述。
Acute pancreatitis is a medical emergency. Alcohol and gallstones are the most common etiologies accounting for 60%-75% cases. Other important causes include postendoscopic retrograde cholangiopancreatography procedure, abdominal trauma, drug toxicity, various infections, autoimmune, ischemia, and hereditary causes. In about 15% of cases the cause remains unknown (idiopathic pancreatitis). Metabolic conditions giving rise to pancreatitis are less common, accounting for 5%-10% cases. The causes include hypertriglyceridemia, hypercalcemia, diabetes mellitus, porphyria, and Wilson's disease. The episodes of pancreatitis tend to be more severe. In cases of metabolic pancreatitis, over and above the standard routine management of pancreatitis, careful management of the underlying metabolic abnormalities is of paramount importance. If not treated properly, it leads to recurrent life-threatening bouts of acute pancreatitis. We hereby review the pathogenesis and management of various causes of metabolic pancreatitis.