Tissue strain amplification at the osteocyte lacuna: A microstructural finite element analysis
Tissue strain amplification at the osteocyte lacuna: A microstructural finite element analysis
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DOI：
10.1016/j.jbiomech.2006.10.040
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Nicolella, Daniel P.
中科院分区：
文献类型：
--
作者：
Bonivtch, Amber Rath;Bonewald, Lynda F.;Nicolella, Daniel P.
建立了骨细胞腔隙的参数化有限元模型，用于预测骨细胞腔隙对宏观应变的微观结构响应。该模型由骨细胞陷窝、骨陷窝周围组织区域、小管和周围骨组织组成。总共45个不同的模拟模型，具有不同的泪小管直径、骨小梁周围组织材料模量和骨小梁周围组织厚度。最大应变增加，而减少在周围的组织模量，并减少在周围的组织模量的增加，无论厚度的周围的区域。随着泪小管直径从0.362 μ m增加到0.421 μ m，观察到预测的最大应变增加。在宏观应变的应用，泪小管直径增加0.8%至超过1.0%，这取决于周围的组织模量。应变放大系数超过3的预测。然而.改变半月板周围组织区域的大小对预测的半月板周围组织应变没有影响。这些结果表明，应用与体内测量的应变水平相似的平均宏观应变可导致明显更大的骨关节腔周围组织应变和泪小管变形。在月旁组织模量的减小放大了月旁组织应变和泪小管变形，而在局部的月旁组织模量的增加减弱了这种效果。(C)2006爱思唯尔有限公司保留所有权利。
A parametric finite element model of an osteocyte lacuna was developed to predict the microstructural response of the lacuna to imposed macroscopic strains. The model is composed of an osteocyte lacuna, a region of perilacunar tissue, canaliculi, and the surrounding bone tissue. A total of 45 different simulations were modeled with varying canalicular diameters, perilacunar tissue material moduli, and perilacunar tissue thicknesses. Maximum strain increased with a decrease in perilacunar tissue modulus and decreased with an increase in perilacunar tissue modulus, regardless of the thickness of the perilacunar region. An increase in the predicted maximum strain was observed with an increase in canalicular diameter from 0.362 to 0.421 pm. In response to the macroscopic application of strain, canalicular diameters increased 0.8% to over 1.0% depending on the perilacunar tissue modulus. Strain magnification factors of over 3 were predicted. However. varying the size of the perilacunar tissue region had no effect on the predicted perilacunar tissue strain. These results indicate that the application of average macroscopic strains similar to strain levels measured in vivo can result in significantly greater perilacunar tissue strains and canaliculi deformations. A decrease in the perilacunar tissue modulus amplifies the perilacunar tissue strain and canaliculi deformation while an increase in the local perilacunar tissue modulus attenuates this effect. (C) 2006 Elsevier Ltd. All rights reserved.