Environmental factors, familial aggregation and heritability of total cholesterol, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol in a Brazilian population assisted by the Family Doctor Program
Environmental factors, familial aggregation and heritability of total cholesterol, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol in a Brazilian population assisted by the Family Doctor Program
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DOI：
10.1016/j.puhe.2011.02.009
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发表时间：
2011-06-01
期刊：
影响因子：
5.2
通讯作者：
Garcia Rosa, M. L.
中科院分区：
文献类型：
--
作者：
de Miranda Chagas, S. V.;Kanaan, S.;Garcia Rosa, M. L.
目的：在巴西某城市家庭医生项目资助的家庭中，评估总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的家族聚集性和遗传性，并评估某些环境因素与这些脂质家族聚集性之间的关联。血脂与社会人口学因素、生活方式因素和合并症（e. G.体力活动、饮酒、吸烟、高血压、葡萄糖耐量受损、体重指数）。采用家族相关程序估计亲属间TC、LDL-C和HDL-C的相关性，并采用ASSOC程序估计遗传度。结果：所有关联均具有统计学意义。TC（父母/子女，r = 0.33;兄弟姐妹/兄弟姐妹，r = 0.37）、LDL-C（父母/子女，r = 0.29;兄弟姐妹/兄弟姐妹，r = 0.37）和HDL-C（父母/子女，r = 0.25;兄弟姐妹/兄弟姐妹，r = 0.48）存在家族聚集性，但分别小于3%、6%和14%，这与生活方式有关。与遗传共享（父母/后代和兄弟姐妹/兄弟姐妹）对之间的相关性高于父亲和母亲之间观察到的。遗传力估计值介于0.32（HDL-C）和0.50（TC）之间。两种方法用于估计遗传和环境因素在家庭对之间TC、LDL-C和HDL-C相关性中的贡献，发现了类似的结果。结果表明，TC、LDL-C、HDL-C存在家族聚集性，并指出遗传因素占主导地位，因为环境变量的影响很小。2011年，皇家公共卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: To estimate familial aggregation and the heritability of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in families assisted by the Family Doctor Program in a Brazilian city, and to evaluate associations between some environmental factors and familial aggregation of these lipids.Study design: Cross-sectional familial study.Methods: The association of lipids with sociodemographic factors, lifestyle factors and comorbidities (e. g. physical activity, alcohol consumption, smoking, hypertension, impaired glucose tolerance, body mass index) was estimated using linear models and generalized estimating equations. Correlation of TC, LDL-C and HDL-C between pairs of relatives was estimated with the familial correlation procedure, and heritability was estimated with the ASSOC procedure.Results: All associations were statistically significant. There was familial aggregation of TC (parent/offspring, r = 0.33; sibling/sibling, r = 0.37), LDL-C (parent/offspring, r = 0.29; sibling/sibling, r 0.37) and HDL-C (parent/offspring, r = 0.25; sibling/sibling, r = 0.48), but less than 3%, 6% and 14%, respectively, which was explained by lifestyle factors. Correlation between pairs with genetic sharing (parent/offspring and sibling/sibling) was higher than that observed between father and mother. Heritability estimates ranged between 0.32 (HDL-C) and 0.50 (TC). Similar results were found for the two approaches used to estimate the contribution of genetic and environmental factors in the correlation of TC, LDL-C and HDL-C between the family pairs.Conclusion: The results showed that there is familial aggregation of TC, LDL-C and HDL-C, and point to the predominance of genetic factors because little influence of environmental variables was found. (C) 2011 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.