Prognostic Relevance of Tn Expression in Breast Cancer.
Prognostic Relevance of Tn Expression in Breast Cancer.
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DOI：
10.1007/bf02967164
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发表时间：
1999-07-25
期刊：
影响因子：
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通讯作者：
Kimijima I
中科院分区：
文献类型：
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作者：
Tsuchiya;Kanno;Kimijima I
背景：异常糖基化模式被认为是癌相关粘蛋白的一个特征。研究乳腺癌组织中Tn抗原的表达以评估其预后相关性。方法：使用219例乳腺癌患者的福尔马林固定、石蜡包埋材料。Tn抗原的免疫组化染色进行了回顾性研究，病变染色10%或以上被认为是阳性结果：Tn抗原表达存在于99（45%）的219个病灶。Tn抗原表达与平均患者年龄、淋巴结状态、雌激素受体状态或绝经状态之间无相关性，但Tn与肿瘤大小之间有轻微显著相关性。Tn抗原阴性患者的生存率明显高于阳性患者。多变量分析还表明，Tn表达与总生存率显着相关，除了淋巴结状态和肿瘤大小。结论：Tn表达是乳腺癌的一个重要预后因素，但在多因素分析中失去了意义。Tn在乳腺癌中表达的生物学意义有待进一步研究。
BACKGROUND: Abnormal glycosylation patterns have been recognized as a featureof carcinomaassociated mucins. The expression of the Tn antigen in breast cancer tissue was investigated to assess its prognostic relevance. METHODS: Formalin-fixed, paraffin-embedded materials from 219 patients with breast cancer were used. Immunohistochemical staining of the Tn antigen was retrospectively investigated and a lesion staining 10% or more was considered positive RESULTS: Tn antigen expression was present in 99 (45%) of 219 lesions. There were no correlations between Tn antigen expression and mean patient age, nodal status, estrogen receptor status, or menopausal status, but there was a slightly significant association between Tn and tumor size. Patients negative for the Tn antigen had a significantly better survival rate than those who were positive. Multivariate analysis also indicated that Tn expression correlated significantly with overall survival in addition to nodal status and tumor size. CONCLUSION: Tn expression was a significant prognostic factor in breast cancer, but the significance was lost on multivariate analysis. The biological implication of Tn expression in breast cancer needs further investigation.